NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS) 28 Medical Drive, #05-01, Singapore 117456.
Nanoscale. 2018 Apr 19;10(15):6812-6819. doi: 10.1039/c7nr08720a.
A hybrid drug delivery platform involving the fusion of cell membranes from U937 monocytes and synthetic lipids to create nano-cell vesicle technology systems (nCVTs) is designed. nCVTs are engineered for a targeted approach towards tumour sites by preserving key surface proteins from U937 monocytes, while being amendable to functionalization and loading due to their liposomal components.
设计了一种混合药物输送平台，涉及将 U937 单核细胞的细胞膜与合成脂质融合，以创建纳米细胞囊泡技术系统 (nCVT)。nCVT 通过保留 U937 单核细胞的关键表面蛋白，针对肿瘤部位进行靶向给药，同时由于其脂质体成分，具有可功能化和加载的特点。
