Zhu Hong, Qian Yuying
Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2018 Jun;46(6):2177-2185. doi: 10.1177/0300060517748842. Epub 2018 Mar 29.
Objective This study aimed to assess the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C for renal dysfunction in older patients with coronary disease. Methods A total of 84 older patients with coronary artery disease were included in this study. Serum NGAL and cystatin C levels were analysed using commercially available kits. Medical data of all patients were recorded and analysed. Results NGAL and cystatin C levels were significantly positively correlated with N-terminal prohormone of brain natriuretic peptide levels and negatively correlated with the estimated glomerular filtration rate. The areas under the receiver operating characteristic curves of serum NGAL and cystatin C levels for diagnosing early renal dysfunction were 0.884 and 0.744, respectively. Conclusion Serum NGAL and cystatin C are potential early and sensitive markers of renal dysfunction in older patients with coronary artery disease.
目的 本研究旨在评估血清中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和胱抑素C对老年冠心病患者肾功能不全的诊断价值。方法 本研究共纳入84例老年冠心病患者。使用市售试剂盒分析血清NGAL和胱抑素C水平。记录并分析所有患者的医学数据。结果 NGAL和胱抑素C水平与脑钠肽前体N端水平显著正相关，与估计肾小球滤过率负相关。血清NGAL和胱抑素C水平诊断早期肾功能不全的受试者工作特征曲线下面积分别为0.884和0.744。结论 血清NGAL和胱抑素C是老年冠心病患者肾功能不全潜在的早期敏感标志物。
