基因变异与骨肉瘤易感性关联的流行病学证据：一项荟萃分析

Epidemiological Evidence for Associations Between Genetic Variants and Osteosarcoma Susceptibility: A Meta-Analysis.

作者信息

Yuan Dechao, Tian Jie, Fang Xiang, Xiong Yan, Banskota Nishant, Kuang Fuguo, Zhang Wenli, Duan Hong

机构信息

Department of Orthopedics, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China.

Department of Thoracic Surgery, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China.

出版信息

Front Oncol. 2022 Jul 4;12:912208. doi: 10.3389/fonc.2022.912208. eCollection 2022.

DOI:10.3389/fonc.2022.912208

PMID:35860595

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9291280/

Abstract

BACKGROUND

Previous studies have showed that single nucleotide polymorphisms (SNPs) might be implicated in the pathogenesis of osteosarcoma (OS). Numerous studies involving SNPs with OS risk have been reported; these results, however, remain controversial and no comprehensive research synopsis has been performed till now.

OBJECTIVE

This study seeks to clarify the relationships between SNPs and OS risk using a comprehensive meta-analysis, and assess epidemiological evidence of significant associations.

METHODS

The PubMed, Web of Science, and Medline were used to screen for articles that evaluated the association between SNP and OS susceptibility in humans before 24 December 2021. Furthermore, we used Venice Criteria and a false positive report probability (FPRP) test to assess the grades of epidemiological evidence for the statistical relationships.

RESULTS

We extracted useful data based on 43 articles, including 10,255 cases and 13,733 controls. Our results presented that 25 SNPs in 17 genes were significantly associated with OS risk. Finally, we graded strong evidence for 17 SNPs in 14 genes with OS risk ( rs1760944, rs3787547, rs231775, rs4150506, rs7958904, rs1800795, rs4073, rs7023329 and rs7027989, rs454006, rs820196, rs1042522, rs3025039, rs699947 and rs2010963, rs1295925, rs861539), moderate for 14 SNPs in 12 genes and weak for 14 SNPs in 11 genes.

CONCLUSION

In summary, this study offered a comprehensive meta-analysis between SNPs and OS susceptibility, then evaluated the credibility of statistical relationships, and provided useful information to identify the appropriate candidate SNPs and design future studies to evaluate SNP factors for OS risk.

摘要

背景

先前的研究表明，单核苷酸多态性（SNP）可能与骨肉瘤（OS）的发病机制有关。已有许多关于SNP与OS风险的研究报道；然而，这些结果仍存在争议，目前尚未进行全面的研究综述。

目的

本研究旨在通过全面的荟萃分析阐明SNP与OS风险之间的关系，并评估显著关联的流行病学证据。

方法

利用PubMed、Web of Science和Medline筛选2021年12月24日前评估SNP与人类OS易感性之间关联的文章。此外，我们使用威尼斯标准和假阳性报告概率（FPRP）测试来评估统计关系的流行病学证据等级。

结果

我们基于43篇文章提取了有用数据，包括10255例病例和13733例对照。我们的结果表明，17个基因中的25个SNP与OS风险显著相关。最后，我们对14个基因中的17个与OS风险相关的SNP（rs1760944、rs3787547、rs231775、rs4150506、rs7958904、rs1800795、rs4073、rs(7023329)和rs(7027989)、rs454006、rs820196、rs1042522、rs3025039、rs699947和rs2010963、rs1295925、rs861539）的证据强度评为强，对12个基因中的14个SNP评为中等，对11个基因中的14个SNP评为弱。