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Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With EGFR-Mutant Advanced Non-Small Cell Lung Cancer.EGFR 突变型晚期非小细胞肺癌患者治疗应答和表皮生长因子受体酪氨酸激酶抑制剂的伴随遗传改变。
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2
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Jpn J Clin Oncol. 2012 Jun;42(6):528-33. doi: 10.1093/jjco/hys042. Epub 2012 Mar 28.
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Non-invasive detection of actionable mutations in advanced non-small-cell lung cancer using targeted sequencing of circulating tumor DNA.利用循环肿瘤 DNA 靶向测序技术无创检测晚期非小细胞肺癌的可操作突变。
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[The concomitant gene alterations impact the therapeutic efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer patients with epidermal growth factor receptor sensitive mutation].[伴随基因改变对表皮生长因子受体敏感突变的晚期非小细胞肺癌患者中表皮生长因子受体酪氨酸激酶抑制剂治疗疗效的影响]
Zhonghua Jie He He Hu Xi Za Zhi. 2018 Oct 12;41(10):778-782. doi: 10.3760/cma.j.issn.1001-0939.2018.10.006.
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Treatment of advanced EGFR-mutant NSCLC patients: Sequencing matters.晚期表皮生长因子受体（EGFR）突变型非小细胞肺癌（NSCLC）患者的治疗：测序至关重要。
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Optimal management of EGFR-mutant non-small cell lung cancer with disease progression on first-line tyrosine kinase inhibitor therapy.表皮生长因子受体（EGFR）突变的非小细胞肺癌在一线酪氨酸激酶抑制剂治疗中出现疾病进展时的优化管理。
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A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor ()-Mutant Lung Adenocarcinoma Who Have Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors.波齐替尼在对表皮生长因子受体（EGFR）-酪氨酸激酶抑制剂产生耐药的EGFR突变型肺腺癌患者中的II期研究。
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A Bayesian network meta-analysis of EGFR-tyrosine kinase inhibitor treatments in patients with mutation-positive non-small cell lung cancer.对表皮生长因子受体（EGFR）-酪氨酸激酶抑制剂治疗EGFR突变阳性非小细胞肺癌患者的贝叶斯网络荟萃分析。
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本文引用的文献

1
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.奥希替尼治疗未经治疗的 EGFR 突变型晚期非小细胞肺癌。
N Engl J Med. 2018 Jan 11;378(2):113-125. doi: 10.1056/NEJMoa1713137. Epub 2017 Nov 18.
2
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.晚期表皮生长因子受体（EGFR）突变型肺癌中共发基因改变的演变及其临床影响
Nat Genet. 2017 Dec;49(12):1693-1704. doi: 10.1038/ng.3990. Epub 2017 Nov 6.
3
Circulating tumor DNA identified by targeted sequencing in advanced-stage non-small cell lung cancer patients.通过靶向测序在晚期非小细胞肺癌患者中鉴定出的循环肿瘤DNA。
Cancer Lett. 2016 Jan 28;370(2):324-31. doi: 10.1016/j.canlet.2015.11.005. Epub 2015 Nov 12.
4
Impact of Specific Epidermal Growth Factor Receptor (EGFR) Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer: A Meta-Analysis.表皮生长因子受体（EGFR）特定突变与临床特征对 EGFR 突变型肺癌患者接受 EGFR 酪氨酸激酶抑制剂与化疗治疗后结局的影响：一项荟萃分析。
J Clin Oncol. 2015 Jun 10;33(17):1958-65. doi: 10.1200/JCO.2014.58.1736. Epub 2015 Apr 20.
5
Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis.表皮生长因子受体酪氨酸激酶抑制剂与野生型表皮生长因子受体非小细胞肺癌的传统化疗：荟萃分析。
JAMA. 2014 Apr 9;311(14):1430-7. doi: 10.1001/jama.2014.3314.
6
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR.吉非替尼或化疗用于治疗具有突变型 EGFR 的非小细胞肺癌。
N Engl J Med. 2010 Jun 24;362(25):2380-8. doi: 10.1056/NEJMoa0909530.

EGFR 突变型晚期非小细胞肺癌患者治疗应答和表皮生长因子受体酪氨酸激酶抑制剂的伴随遗传改变。

Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With EGFR-Mutant Advanced Non-Small Cell Lung Cancer.

机构信息

State Key Laboratory of Oncology in South China, Guangzhou.

Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

出版信息

JAMA Oncol. 2018 May 1;4(5):739-742. doi: 10.1001/jamaoncol.2018.0049.

DOI:10.1001/jamaoncol.2018.0049
PMID:29596544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5885210/
Abstract

This cohort study examines the association of concomitant genetics alterations with response to treatment with epidermal growth factor receptor tyrosine kinase inhibitors among patients with -mutant advanced non–small cell lung cancer.

摘要

本队列研究探讨了 - 突变型晚期非小细胞肺癌患者中伴随的基因改变与表皮生长因子受体酪氨酸激酶抑制剂治疗反应之间的关系。