Serrano-Dueñas Marcos, Bravo Rosaura, Merchán Tamara, Serrano Maite
Medicine Faculty, Pontifical Catholic University of Ecuador, Neurological Service, Carlos Andrade Marin Hospital, Quito-Ecuador, Ecuador.
Clin Neurol Neurosurg. 2018 Jun;169:12-15. doi: 10.1016/j.clineuro.2018.03.020. Epub 2018 Mar 22.
In Parkinson's disease patients, fatigue is a disabling non-motor symptom whose prevalence ranges from 28% to 58%. The Fatigue Impact Scale for Daily Use (D-FIS), one of the various scales for quantifying fatigue. The aim of our study was to analyze the metric properties of the D-FIS in PD subjects and assess the impact of fatigue on their quality of life.
The cohort in this study was comprised of 211 consecutive patients with a PD diagnosis regularly followed up at the Movement Disorders Unit of the Neurology Department at Carlos Andrade Marín Hospital (HCAM) in Quito, Ecuador, according to the United Kingdom PD Society Brain Bank criteria. Data Quality, Acceptability, Reliability, Stability (test-retest), Validity and Multiple linear regression analysis were determined.
The final sample consisted of 138 men (65.4%) and 73 women. Forty-six percent of these (98 patients) were in stage II of H&Y. We obtained a Cronbach's α value of 0.912 and an ICC value of 0.79. D-FIS was strongly correlated with depression (Spearman rho [Srho] 0.60), anxiety (Srho 0.59), quality of life (Srho 0.67), and non-motor symptoms (Srho 0.66). The scale's discriminant validity, assessed among the different stages of H&Y by the Kruskal-Wallis test, showed major significance (X = 23.183, p ≤ 0.001). In the Multiple linear regression study, the resulting model proves that fatigue has a determining effect on quality of life.
The D-FIS has good metric properties and demonstrates that fatigue significantly affects PD patients' quality of life and that its impact is independent from that of anxiety, depression, and sleep disorders.
在帕金森病患者中，疲劳是一种致残性非运动症状，其患病率在28%至58%之间。日常疲劳影响量表（D-FIS）是用于量化疲劳的多种量表之一。我们研究的目的是分析D-FIS在帕金森病患者中的计量学特性，并评估疲劳对其生活质量的影响。
本研究队列由211例连续的帕金森病诊断患者组成，这些患者按照英国帕金森病协会脑库标准，在厄瓜多尔基多市卡洛斯·安德拉德·马林医院（HCAM）神经科运动障碍科定期随访。测定了数据质量、可接受性、信度、稳定性（重测）、效度和多元线性回归分析。
最终样本包括138名男性（65.4%）和73名女性。其中46%（98例患者）处于H&Y分期的II期。我们得到的克朗巴哈α值为0.912，组内相关系数值为0.79。D-FIS与抑郁（斯皮尔曼等级相关系数[Srho] 0.60）、焦虑（Srho 0.59）、生活质量（Srho 0.67）和非运动症状（Srho 0.66）密切相关。通过Kruskal-Wallis检验在H&Y不同分期中评估的量表判别效度显示具有显著意义（X = 23.183，p ≤ 0.001）。在多元线性回归研究中，所得模型证明疲劳对生活质量有决定性影响。
D-FIS具有良好的计量学特性，表明疲劳显著影响帕金森病患者的生活质量，且其影响独立于焦虑、抑郁和睡眠障碍。
