Cappa Stefano F
Institute for Advanced Studies (IUSS), Pavia, Italy.
IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Front Neurol. 2018 Mar 1;9:108. doi: 10.3389/fneur.2018.00108. eCollection 2018.
This mini-review considers three different approaches to the therapy and prevention of Alzheimer's disease (AD): replacement therapy, disease modification, and multi-level interventions. Each of these research frameworks has direct implications at the clinical level, leading to an emphasis on different time points of the AD continuum. While all perspectives continue to play an important role in current efforts to reach the ambitious target of an effective therapy or prevention of AD by 2025, it is clear that novel paradigms are needed, including new models of clinical trial design. This goal can only be accomplished by a concerted effort of academia, governmental agencies, and industry.
本综述探讨了治疗和预防阿尔茨海默病（AD）的三种不同方法：替代疗法、疾病修饰疗法和多层次干预。这些研究框架中的每一种在临床层面都有直接影响，导致对AD病程不同时间点的重视。虽然所有观点在当前为实现到2025年有效治疗或预防AD这一宏伟目标所做的努力中仍发挥着重要作用，但显然需要新的范式，包括新的临床试验设计模式。这一目标只能通过学术界、政府机构和行业的共同努力来实现。
