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Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages.人间充质干细胞在细胞治疗中的应用：优点与缺点。
Dev Reprod. 2017 Mar;21(1):1-10. doi: 10.12717/DR.2017.21.1.001. Epub 2017 Mar 31.
2
Counteracting bone fragility with human amniotic mesenchymal stem cells.用人类羊膜间充质干细胞对抗骨质脆弱。
Sci Rep. 2016 Dec 20;6:39656. doi: 10.1038/srep39656.
3
Comparing the Immunomodulatory Properties of Bone Marrow, Adipose Tissue, and Birth-Associated Tissue Mesenchymal Stromal Cells.比较骨髓、脂肪组织和出生相关组织间充质基质细胞的免疫调节特性。
Front Immunol. 2015 Nov 3;6:560. doi: 10.3389/fimmu.2015.00560. eCollection 2015.
4
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.间充质干细胞利用细胞外囊泡来外包线粒体自噬并穿梭运输微小RNA。
Nat Commun. 2015 Oct 7;6:8472. doi: 10.1038/ncomms9472.
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Nosology and classification of genetic skeletal disorders: 2015 revision.遗传性骨骼疾病的疾病分类学与分类：2015年修订版
Am J Med Genet A. 2015 Dec;167A(12):2869-92. doi: 10.1002/ajmg.a.37365. Epub 2015 Sep 23.
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Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles.多能间充质基质细胞及其细胞外囊泡的治疗潜力
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Stem Cell Therapies in Clinical Trials: Progress and Challenges.临床试验中的干细胞疗法：进展与挑战。
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Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications.间充质干细胞衍生的细胞外囊泡：迈向无细胞治疗应用
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Human mesenchymal stem cells - current trends and future prospective.人间充质干细胞——当前趋势与未来展望。
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10
Non-invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: next-generation sequencing allows for a safer, more accurate, and comprehensive approach.软骨发育不全和致死性骨发育不良的非侵入性产前诊断：新一代测序提供了一种更安全、更准确且更全面的方法。
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胎儿间充质基质细胞：产前细胞治疗的一个契机。

Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy.

作者信息

Sagar Rachel, Walther-Jallow Lilian, David Anna L, Götherström Cecilia, Westgren Magnus

机构信息

1Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX UK.

2Department of Clinical Science, Intervention and Technology, K57, Division of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden.

出版信息

Curr Stem Cell Rep. 2018;4(1):61-68. doi: 10.1007/s40778-018-0118-8. Epub 2018 Feb 15.

DOI:10.1007/s40778-018-0118-8
PMID:29600162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5866262/
Abstract

PURPOSE OF REVIEW

The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs).

RECENT FINDINGS

MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in culture. Their ability to migrate, engraft and differentiate, or act via a paracrine effect on target tissues makes MSCs candidates for clinical therapies. Fetal and extra-fetal MSCs offer higher therapeutic potential compared to MSCs derived from adult sources.

SUMMARY

MSCs may be safely transplanted prenatally via ultrasound-guided injection into the umbilical cord. Due to these characteristics, fetal MSCs are of great interest in the field of in utero stem cell transplantation for treatment of congenital disease.

摘要

综述目的

本研究旨在概述使用间充质基质细胞（MSCs）进行产前治疗先天性疾病的可能性。

最新发现

MSCs具有多向分化潜能且免疫原性低，具有免疫调节作用且在培养中更易于扩增。它们的迁移、植入和分化能力，或通过旁分泌作用作用于靶组织的能力使MSCs成为临床治疗的候选者。与源自成人的MSCs相比，胎儿和胎儿外MSCs具有更高的治疗潜力。

总结

MSCs可以通过超声引导注射安全地进行产前移植到脐带中。由于这些特性，胎儿MSCs在子宫内干细胞移植治疗先天性疾病领域引起了极大的兴趣。