Department of Experimental Medicine, University of Perugia, Perugia, Italy.
Division of Medical Andrology and Endocrinology of Reproduction, University of Perugia and Saint Mary Hospital, Terni, Italy.
Andrology. 2018 May;6(3):385-395. doi: 10.1111/andr.12484. Epub 2018 Mar 30.
Sertoli cells are located in the testes where they control several key functions in spermatogenesis. Over the past 30 years, Sertoli cells have been upgraded from a simple scaffold-like structural system to a dynamic functional system of intercellular support that delivers potent immunomodulatory and trophic factors. Since the discovery of new Sertoli cell secretory products, these cells have been utilized in experimental cell transplantation and co-transplantation protocols aimed at treating both chronic inflammatory and degenerative disorders. For these reasons, this work reviews the application of both naked and microencapsulated Sertoli cells used in cell transplantation studies of several chronic or autoimmune diseases such as diabetes mellitus, Laron dwarfism, and Duchenne muscular dystrophy and in studies aimed at the prevention of skin allograft rejection.
支持细胞位于睾丸中，它们控制着精子发生中的几个关键功能。在过去的 30 年中，支持细胞已经从简单的支架样结构系统升级为具有细胞间支持功能的动态功能系统，能够提供有效的免疫调节和营养因子。自发现新的支持细胞分泌产物以来，这些细胞已被用于实验性细胞移植和共移植方案中，旨在治疗慢性炎症和退行性疾病。基于这些原因，本研究综述了裸细胞和微囊化支持细胞在几种慢性或自身免疫性疾病（如糖尿病、拉伦侏儒症和杜氏肌营养不良症）的细胞移植研究中的应用，以及在预防皮肤同种异体移植排斥反应的研究中的应用。
