Willing A E, Cameron D F, Sanberg P R
Division of Neurosurgery, University of South Florida College of Medicine, Tampa 33612, USA.
Mol Med Today. 1998 Nov;4(11):471-7. doi: 10.1016/s1357-4310(98)01355-0.
The efficacy of treating neurodegenerative diseases with the transplantation of fetal tissue has been demonstrated in animal models of Parkinson's disease, Huntington's disease and stroke. In the clinical setting, neural transplantation as a treatment for patients with Parkinson's disease has shown promising results. However, for this treatment method to be effective neuronal survival needs to be improved through either trophic support or localized immunoprotection. Co-transplanting Sertoli cells, which express many nutritive, regulatory, trophic and immunosuppressive factors, with fetal neural cells could provide both of these requirements. Such a strategy could enhance the recovery benefits associated with transplantation and decrease the need for, and the risks associated with, long-term systemic immunosuppression.
在帕金森病、亨廷顿舞蹈症和中风的动物模型中，已证实胎儿组织移植治疗神经退行性疾病的疗效。在临床环境中，神经移植作为帕金森病患者的一种治疗方法已显示出有前景的结果。然而，要使这种治疗方法有效，需要通过营养支持或局部免疫保护来提高神经元的存活率。将表达多种营养、调节、营养和免疫抑制因子的支持细胞与胎儿神经细胞共同移植，可以满足这两个要求。这样的策略可以增强与移植相关的恢复益处，并减少长期全身免疫抑制的需求和相关风险。
