Feng Xue, Fang Sai-Nan, Gao Yu-Xin, Liu Jian-Ping, Chen Wei
Centre for Evidence-Based Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China.
Department of Sociology， Acadia University， Wolfville B4P2R6， Canada.
Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(3):446-451. doi: 10.19540/j.cnki.cjcmm.20171211.002.
To investigate the feasibility of applying the evidence-based rapid review in studying the nephrotoxicity of Tripterygium wilfordii preparation. We used four methods in relevant studies on the nephrotoxicity of T. wilfordii preparation. The first method had no limitation on any search terms， which was a traditional approach to retrieve systematic reviews. The second method limited the relevant search terms of T. wilfordii preparation to "all of CHMs containing T. wilfordii preparation approved by CFDA". The third method was to limit the relevant retrieval terms of nephrotoxicity as the "most frequently reported terms related to nephrotoxicity found in the study literature screening process in the early stage of systematic review". The fourth method was to limit the search terms relating to both T. wilfordii preparation and nephrotoxicity. Finally， the results of the last three search methods were compared with those of the first search method， and the feasibility of the rapid review method in the study for the nephrotoxicity of CHM was discussed. For the total number of literatures searched， the fourth method had the smallest number of literatures. For the number of articles in line with the inclusion criteria， the second method had the largest number of eligible literatures. For the type of literatures included， the forth method had a higher coincidence degree. The forth method was the best one， because it was not only consistent with the results， but also could minimize the workload. Rapid review is feasible in the study of nephrotoxicity of T. wilfordii.
为探讨循证快速评价法在雷公藤制剂肾毒性研究中的应用可行性。我们在雷公藤制剂肾毒性的相关研究中采用了四种方法。第一种方法对任何检索词均无限制，这是检索系统评价的传统方法。第二种方法将雷公藤制剂的相关检索词限定为“所有经CFDA批准的含雷公藤制剂的中药”。第三种方法是将肾毒性的相关检索词限定为“在系统评价前期研究文献筛选过程中发现的与肾毒性最常相关的术语”。第四种方法是对与雷公藤制剂和肾毒性相关的检索词均进行限定。最后，将后三种检索方法的结果与第一种检索方法的结果进行比较，并讨论快速评价法在中药肾毒性研究中的可行性。就检索到的文献总数而言，第四种方法检索到的文献数量最少。就符合纳入标准的文章数量而言，第二种方法纳入的合格文献数量最多。就纳入文献的类型而言，第四种方法的吻合度较高。第四种方法是最佳方法，因为它不仅与结果一致，而且能将工作量降至最低。快速评价法在雷公藤肾毒性研究中是可行的。
