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[中药炮制用姜汁辅料的冷冻干燥工艺优化及冻干姜汁水粉的稳定性]

[Freeze drying process optimization of ginger juice-adjuvant for Chinese materia medica processing and stability of freeze-dried ginger juice powder].

作者信息

Yang Chun-Yu, Guo Feng-Qian, Zang Chen, Cao Hui, Zhang Bao-Xian

机构信息

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

School of Pharmacy, Ji'nan University, Guangzhou 510632, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(3):520-526. doi: 10.19540/j.cnki.cjcmm.20171208.008.

DOI:10.19540/j.cnki.cjcmm.20171208.008
PMID:29600616
Abstract

Ginger juice, a commonly used adjuvant for Chinese materia medica, is applied in processing of multiple Chinese herbal decoction pieces. Because of the raw materials and preparation process of ginger juice, it is difficult to be preserved for a long time, and the dosage of ginger juice in the processing can not be determined base on its content of main compositions. Ginger juice from different sources is hard to achieve consistent effect during the processing of traditional Chinese herbal decoction pieces. Based on the previous studies, the freeze drying of ginger juice under different shelf temperatures and vacuum degrees were studied, and the optimized freeze drying condition of ginger juice was determined. The content determination method for 6-gingerol, 8-gingerol, 10-gingerol and 6-shagaol in ginger juice and redissolved ginger juice was established. The content changes of 6-gingerol, 8-gingerol, 10-gingerol, 6-gingerol, 6-shagaol, volatile oil and total phenol were studied through the drying process and 30 days preservation period. The results showed that the freeze drying time of ginger juice was shortened after process optimization; the compositions basically remained unchanged after freeze drying, and there was no significant changes in the total phenol content and gingerol content, but the volatile oil content was significantly decreased(<0.05). Within 30 days, the contents of gingerol, total phenol, and volatile oil were on the decline as a whole. This study has preliminarily proved the feasibility of freeze-drying process of ginger juice as an adjuvant for Chinese medicine processing.

摘要

姜汁作为中药常用辅料,应用于多种中药饮片炮制。由于姜汁的原料及制备工艺,其难以长期保存,且在炮制中姜汁用量无法依据其主要成分含量来确定。不同来源的姜汁在中药饮片炮制过程中难以达到一致效果。基于前期研究,对不同搁板温度和真空度下姜汁的冷冻干燥进行了研究,确定了姜汁的优化冷冻干燥条件。建立了姜汁及复溶姜汁中6-姜酚、8-姜酚、10-姜酚和6-姜辣素的含量测定方法。研究了6-姜酚、8-姜酚、10-姜酚、6-姜酚、6-姜辣素、挥发油和总酚在干燥过程及30天保存期内的含量变化。结果表明,优化工艺后姜汁冷冻干燥时间缩短;冷冻干燥后成分基本不变,总酚含量和姜酚含量无显著变化,但挥发油含量显著降低(<0.05)。30天内,姜酚、总酚和挥发油含量总体呈下降趋势。本研究初步证明了姜汁冷冻干燥工艺作为中药炮制辅料的可行性。

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