Zhou Hong-Chao, Du Rui, Wang Hui, Zeng Fan-Li, Shi Kun, Li Jian-Ming, Zong Ying
College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China.
Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education of the People's Republic of China, Laboratory of Production and Product Application of Sika Deer of Jilin Province, Changchun 130118, China.
Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(4):684-688. doi: 10.19540/j.cnki.cjcmm.20171106.011.
Scutellariae baicalensis is one of the most important traditional Chinese medicinal herbs, mainly distributed in Shandong and Hebei provinces. It has significant pharmacological effects such as antimicrobial activity, anti-inflammatory and antioxidation. Baicalin is one of its main effective components. However, baicalin's low bioavailability has restricted its clinical application. In recent decades, extensive studies have been carried out on the metabolism of baicalin at home and abroad. In order to provide scientific references for baicalin's further studies, this paper would not only review the advances in pharmacokinetics research of baicalin and Chinese herbal preparations containing baicalin, but also make a summary on research status of baicalin.
黄芩是最重要的传统中草药之一，主要分布于山东和河北省。它具有抗菌、抗炎和抗氧化等显著药理作用。黄芩苷是其主要有效成分之一。然而，黄芩苷的低生物利用度限制了其临床应用。近几十年来，国内外对黄芩苷的代谢进行了广泛研究。为了为黄芩苷的进一步研究提供科学参考，本文不仅将综述黄芩苷及含黄芩苷的中药制剂的药代动力学研究进展，还将对黄芩苷的研究现状进行总结。
