Core Facilities, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Mediators Inflamm. 2023 May 4;2023:6653202. doi: 10.1155/2023/6653202. eCollection 2023.
Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which causes membrane injury. Under the catalysis of iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve the balance in lipid oxidative metabolism, and the buildup of reactive oxygen species on the membrane lipids leads to cell death. An increasing body of evidence suggests that ferroptosis plays a significant role in the development and occurrence of cardiovascular diseases. In this paper, we mainly elaborated on the molecular mechanisms regulating ferroptosis and its impact on cardiovascular disease to lay the groundwork for future studies on the prophylaxis and treatment of this patient population.
铁死亡是一种新型的程序性细胞死亡方式，其特征是铁依赖性脂质过氧化物的积累，导致膜损伤。在铁离子的催化作用下，谷胱甘肽过氧化物酶 (GPX4) 缺乏的细胞无法维持脂质氧化代谢的平衡，膜脂质上活性氧的积累导致细胞死亡。越来越多的证据表明，铁死亡在心血管疾病的发展和发生中起着重要作用。本文主要阐述了调节铁死亡的分子机制及其对心血管疾病的影响，为研究该患者人群的预防和治疗奠定了基础。
