Department of Toxicology, Faculty of Pharmacy, Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland.
Mini Rev Med Chem. 2018;18(15):1321-1330. doi: 10.2174/1389557518666180330101809.
Indandione is a hydrocarbon classified as bicyclic aromatic β-diketone. It can be applied in many fields of science and industry. It is successfully used as a substrate in organic synthesis, pharmaceutical sciences and as a substrate for the production of dyes. Indandione derivatives and analogs are useful in medicine, chemistry and the judiciary. Among the indandione derivatives can find compounds that have interesting properties and many of them have biological activity (incl. anticancer, anticoagulation, anti-inflamatory, antimicrobial activities). Based on the indan-1,3-dione structure created acetylcholinesterase inhibitors. Indan-1,3-dione derivatives are also used as a derivating agent for the analysis of fatty aldehydes and a substance that is an element of dye-sensitized solar cells. This work presents a brief overview of construction, properties and activities of indandione and its derivatives. This work describes selected indandione derivatives that have properties useful in medicine and industry with particular regard to the anticoagulants and neuroprotective activities in AD.
茚满二酮是一种被归类为双环芳香β-二酮的碳氢化合物。它可以应用于科学和工业的许多领域。它已成功地用作有机合成、药物科学和生产染料的底物。茚满二酮衍生物和类似物在医学、化学和司法领域都有应用。在茚满二酮衍生物中可以发现具有有趣性质的化合物，其中许多具有生物活性（包括抗癌、抗凝、抗炎、抗菌活性）。基于茚-1,3-二酮结构，合成了乙酰胆碱酯酶抑制剂。茚-1,3-二酮衍生物也可用作脂肪酸醛分析的衍生剂和染料敏化太阳能电池的组成部分。本文简要概述了茚满二酮及其衍生物的结构、性质和活性。本文描述了一些具有医学和工业应用价值的茚满二酮衍生物，特别关注它们在 AD 中的抗凝和神经保护活性。
