牙周组织生物工程：未来已来？

Periodontal Tissue Bioengineering: Is the Future Now?

作者信息

Fretwurst Tobias, Larsson Lena, Yu Shan Huey, Pilipchuk Sophia P, Kaigler Darnell, Giannobile William V

机构信息

Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, Michigan; Department of Oral and Craniomaxillofacial Surgery, Center for Dental Medicine, University Medical Center Freiburg, Freiburg, Germany.

Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, Michigan; Department of Periodontology, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.

出版信息

Compend Contin Educ Dent. 2018 Apr;39(4):218-223; quiz 224.

PMID:29600869

Abstract

Periodontitis affects nearly half of the adult population in the United States and leads to periodontium destruction, tooth loss, and tooth mobility. Novel bioengineering has become an area of interest in dentistry, as various approaches aim to regenerate attachment apparatus around diseased teeth with the use of barriers, scaffolds, bone grafts, or biologics. This article emphasizes recent findings in the fields of stem cell/gene therapy, 3-dimensional printing, and innovative scaffold designs for future applications in clinical care.

摘要

在美国，牙周炎影响着近一半的成年人口，并导致牙周组织破坏、牙齿脱落和牙齿松动。新型生物工程已成为牙科领域的一个研究热点，因为各种方法旨在利用屏障、支架、骨移植或生物制剂在患病牙齿周围再生附着装置。本文重点介绍干细胞/基因治疗、三维打印以及创新支架设计领域的最新研究成果，以供未来临床应用参考。