Division of Research and Analysis, Food and Drug Administration, Ministry of Health and Welfare, No.161-2, Kunyang St., Nangang District, Taipei City 115-61, Taiwan.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, No.91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
J Pharm Biomed Anal. 2018 Sep 5;158:257-261. doi: 10.1016/j.jpba.2018.05.049. Epub 2018 Jun 1.
A novel tadalafil analogue, which exhibits similarity to 2-hydroxypropylnortadalafil, was found in dietary supplements using adulterants screening and isolated using column chromatography. By using extensive 1D- and 2D-NMR and MS spectral analyses, the structure was determined as 6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(3-hydroxypropyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione, and the analogue was named N-3-hydroxypropylnortadalafil.
一种新型的他达那非类似物，其结构与 2-羟丙基那他非相似，在使用掺杂物筛选的膳食补充剂中被发现，并通过柱层析法分离得到。通过广泛的 1D 和 2D-NMR 和 MS 光谱分析，确定其结构为 6-(1,3-苯并二恶唑-5-基)-2,3,6,7,12,12a-六氢-2-(3-羟丙基)吡嗪并(1',2':1,6)吡啶并(3,4-b)吲哚-1,4-二酮，该类似物被命名为 N-3-羟丙基那他非。
