Hypertension in Africa Research Team, Faculty of Health Sciences.
MRC Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
J Hypertens. 2018 Aug;36(8):1689-1696. doi: 10.1097/HJH.0000000000001740.
Masked hypertension is reportedly common in young adults. However, it is unknown if these masked hypertensive individuals already present with organ damage. We determined whether a relationship exists between left ventricular structure and function, and masked hypertension in young healthy adults.
In this cross-sectional study, we included 774 black and white men and women (aged 20-30 years) who had successful ambulatory blood pressure monitoring readings (>70% valid readings) and valid echocardiography done.
We found that 16.4% had masked hypertension (60.6% whites; 67.7% men). When performing multivariable-adjusted logistic regression, we found masked hypertensive patients to have higher odds to present with increased left ventricular mass index (odds ratio 1.67, P = 0.031) compared to normotensive individuals. In multivariable-adjusted linear regression analyses, left ventricular mass index positively and independently associated with masked hypertension [adjusted R = 0.193, β = 0.08 (0.01; 0.16), P = 0.046]. However, we found no independent link between echocardiographic measures of left ventricular function and masked hypertension.
This study highlights the importance of the early detection of masked hypertension as young apparently healthy adults already show an increased left ventricular mass index, thereby indicating increased risk for future cardiovascular disease.
据报道，隐匿性高血压在年轻人中较为常见。然而，目前尚不清楚这些隐匿性高血压患者是否已经存在器官损伤。本研究旨在确定年轻健康成年人的左心室结构和功能与隐匿性高血压之间是否存在关系。
在这项横断面研究中，我们纳入了 774 名黑人和白人（年龄 20-30 岁），这些人成功进行了动态血压监测（>70%有效读数）和有效的超声心动图检查。
我们发现 16.4%的患者患有隐匿性高血压（60.6%为白人；67.7%为男性）。在进行多变量调整后的逻辑回归分析中，我们发现与正常血压患者相比，隐匿性高血压患者的左心室质量指数（LVMI）更高（比值比 1.67，P=0.031）。在多变量调整后的线性回归分析中，LVMI 与隐匿性高血压呈正相关且独立相关[调整后的 R2=0.193，β=0.08（0.01；0.16），P=0.046]。然而，我们没有发现左心室功能的超声心动图指标与隐匿性高血压之间存在独立联系。
本研究强调了早期发现隐匿性高血压的重要性，因为年轻的健康成年人已经表现出左心室质量指数增加，这表明未来发生心血管疾病的风险增加。
