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本文引用的文献

1
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.对 480,000 名成年人的冠心病的基因组风险预测：对一级预防的影响。
J Am Coll Cardiol. 2018 Oct 16;72(16):1883-1893. doi: 10.1016/j.jacc.2018.07.079.
2
Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.使用来自 32 种复杂性状的全基因组关联研究的汇总水平统计数据估计复杂效应大小分布。
Nat Genet. 2018 Sep;50(9):1318-1326. doi: 10.1038/s41588-018-0193-x. Epub 2018 Aug 13.
3
Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events.遗传易感性与高血压和生活方式因素：与中年血压水平和心血管事件的关联。
Circulation. 2018 Feb 13;137(7):653-661. doi: 10.1161/CIRCULATIONAHA.117.030898. Epub 2017 Dec 18.
4
First things first: risk model performance metrics should reflect the clinical application.首先：风险模型性能指标应反映临床应用情况。
Stat Med. 2017 Dec 10;36(28):4503-4508. doi: 10.1002/sim.7341.
5
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2017美国心脏病学会/美国心脏协会/美国医师协会/美国心脏病学学会/美国预防医学学院/美国老年病学会/美国药学协会/美国血液学会/美国预防医学学会/美国医学协会/美国初级保健医师学会成人高血压预防、检测、评估和管理指南：美国心脏病学会/美国心脏协会临床实践指南工作组报告
J Am Coll Cardiol. 2018 May 15;71(19):e127-e248. doi: 10.1016/j.jacc.2017.11.006. Epub 2017 Nov 13.
6
Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study.冠心病遗传风险评分对降低心血管风险的影响：一项试点随机对照研究。
Front Cardiovasc Med. 2017 Aug 14;4:53. doi: 10.3389/fcvm.2017.00053. eCollection 2017.
7
Informed Consent.知情同意书
N Engl J Med. 2017 Mar 2;376(9):856-867. doi: 10.1056/NEJMra1603773.
8
Genetics: Implications for Prevention and Management of Coronary Artery Disease.遗传学：对冠状动脉疾病的预防和管理的启示。
J Am Coll Cardiol. 2016 Dec 27;68(25):2797-2818. doi: 10.1016/j.jacc.2016.10.039.
9
Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study.从智能手机应用程序获取生活方式措施的可行性：MyHeart Counts 心血管健康研究。
JAMA Cardiol. 2017 Jan 1;2(1):67-76. doi: 10.1001/jamacardio.2016.4395.
10
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.遗传风险、对健康生活方式的坚持与冠心病
N Engl J Med. 2016 Dec 15;375(24):2349-2358. doi: 10.1056/NEJMoa1605086. Epub 2016 Nov 13.

心血管疾病：遗传风险评分的崛起。

Cardiovascular disease: The rise of the genetic risk score.

机构信息

Center for Inherited Cardiovascular Disease, Stanford University, Stanford, California, United States of America.

出版信息

PLoS Med. 2018 Mar 30;15(3):e1002546. doi: 10.1371/journal.pmed.1002546. eCollection 2018 Mar.

DOI:10.1371/journal.pmed.1002546
PMID:29601582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5877829/
Abstract

In a Perspective, Joshua Knowles and Euan Ashley discuss the potential for use of genetic risk scores in clinical practice.

摘要

在一篇观点文章中，Joshua Knowles 和 Euan Ashley 探讨了遗传风险评分在临床实践中的应用潜力。