Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
PLoS One. 2018 Mar 30;13(3):e0195230. doi: 10.1371/journal.pone.0195230. eCollection 2018.
Preservation of residual hearing after cochlear implant is an important issue with regards to hearing performance. Various methods of steroid administration have been widely used in clinical practice to reduce inflammation and preserve residual hearing. Here we compare the effect of different routes of dexamethasone administration on intracochlear inflammation and residual hearing in guinea pig ears. Dexamethasone was delivered into the guinea pigs either through intracochlear, intratympanic or systemic route. The intracochlear concentration of dexamethasone, residual hearing, inflammatory cytokines and histopathologic changes were evaluated over time. A higher intracochlear dexamethasone concentration was observed after intracochlear administration than through the other routes. Residual hearing was better preserved with local dexamethasone administration as was supported by the reduced inflammatory cytokines, more hair cell survival and less severe intracochlear fibrosis and ossification concurrently seen in the local delivery group than in the systemic group. The results demonstrate that local dexamethasone delivery can reduce intracochlear inflammation and preserve residual hearing better than in systemically administered dexamethasone.
保留人工耳蜗植入后的残余听力对于听力表现非常重要。在临床实践中，已经广泛使用各种类固醇给药方法来减轻炎症并保留残余听力。在这里，我们比较了不同途径给予地塞米松对豚鼠耳蜗内炎症和残余听力的影响。地塞米松通过耳蜗内、鼓室内或全身途径给予豚鼠。随着时间的推移，评估了地塞米松在耳蜗内的浓度、残余听力、炎症细胞因子和组织病理学变化。与其他途径相比，耳蜗内给药后观察到更高的地塞米松在耳蜗内浓度。局部地塞米松给药更好地保留了残余听力，这与炎症细胞因子减少、毛细胞存活更多以及耳蜗内纤维化和骨化程度较轻有关，这些在局部给药组中比在全身给药组中更为明显。结果表明，局部地塞米松给药可减轻耳蜗内炎症并更好地保留残余听力，优于全身给予地塞米松。
