用于瘢痕管理的局部用药：它们有效吗？

Topical Agents for Scar Management: Are They Effective?

作者信息

Zoumalan Christopher I

出版信息

J Drugs Dermatol. 2018 Apr 1;17(4):421-425.

Abstract

Scar formation is the body's natural healing response to reestablish dermal integrity following an injury. Excessive scarring, however, can cause significant cosmetic, functional, and psychological problems. A wide variety of topical creams, lotions, and oils are available for scar treatment or wound healing. Sieving through the options and selecting the best option for their patients can be challenging for clinicians, especially given that clinical evidence for many of the active agents in commonly used topical treatments is lacking. The goal of this review is to provide an overview of topical treatments utilized for scar management, including their mechanism of action and evidence of efficacy. As knowledge of the wound healing process is critical to understanding the effects of topical treatments, the pathophysiology of wound healing is also reviewed.

J Drugs Dermatol. 2018;17(4):421-425.

摘要

瘢痕形成是身体在受伤后重新建立皮肤完整性的自然愈合反应。然而，过度瘢痕化会导致严重的美容、功能和心理问题。有各种各样的外用乳膏、洗剂和油剂可用于瘢痕治疗或伤口愈合。对于临床医生来说，筛选这些选项并为患者选择最佳选项可能具有挑战性，尤其是考虑到常用局部治疗中许多活性剂缺乏临床证据。本综述的目的是概述用于瘢痕管理的局部治疗方法，包括其作用机制和疗效证据。由于对伤口愈合过程的了解对于理解局部治疗的效果至关重要，因此也对伤口愈合的病理生理学进行了综述。

《皮肤药物学杂志》。2018年；17(4):421 - 425。