University of Virginia, School of Medicine, Charlottesville, Virginia.
Dermatology Research and Education Foundation, Irvine, California.
Dermatol Surg. 2020 Dec;46(12):1564-1571. doi: 10.1097/DSS.0000000000002712.
There is an increasing number of over-the-counter topical products that are said to prevent pathologic scar formation and improve scar cosmesis. However, robust clinical data are lacking to substantiate these claims and to guide selection of topical products.
To determine the effectiveness of topical scar management products, including silicone gel, Allium cepa onion extract, vitamin E, trolamine, and microporous tape.
A PubMed search (2005-2019) was performed to identify studies of topical scar management products. Randomized controlled trials (RCTs), quasi-RCTs, meta-analyses, and controlled clinical trials were included for analysis.
A total of 34 trials were included in this study. Of the 16 trials investigating silicone gel sheets, numerous high-quality RCTs found that silicone gel sheets and silicone gels significantly improved scar outcomes. Only a limited number of studies supported the effectiveness of onion extract, vitamin E, trolamine, and microporous tape products.
Silicone gel products are an effective noninvasive treatment to prevent formation of pathologic scars and improve mature scars. Further high-quality studies are needed to elucidate the long-term effectiveness of these therapies.
市面上有越来越多的非处方外用产品，据称可预防病理性瘢痕形成并改善瘢痕美观。然而，缺乏强有力的临床数据来证实这些说法，并指导外用产品的选择。
确定外用瘢痕管理产品（包括硅凝胶、洋葱提取物、维生素 E、三乙醇胺和微孔胶带）的有效性。
对 PubMed（2005-2019 年）进行检索，以确定外用瘢痕管理产品的研究。纳入了随机对照试验（RCT）、准 RCT、荟萃分析和对照临床试验进行分析。
本研究共纳入 34 项试验。在 16 项研究硅凝胶片的试验中，大量高质量 RCT 发现硅凝胶片和硅凝胶显著改善了瘢痕结局。仅有少数研究支持洋葱提取物、维生素 E、三乙醇胺和微孔胶带产品的有效性。
硅凝胶产品是预防病理性瘢痕形成和改善成熟瘢痕的有效非侵入性治疗方法。需要进一步的高质量研究来阐明这些治疗方法的长期效果。
