Epidemiology and Microbial Genomics, Laboratoire National de Santé, 1 rue Louis Rech, L-3555 Dudelange, Luxembourg.
Unit of Cancer Epidemiology, Belgian Cancer Centre, Scientific Institute of Public Health, Rue Juliette Wytsman 14, 1050 Ixelles, Belgium.
Vaccine. 2018 Apr 25;36(18):2411-2416. doi: 10.1016/j.vaccine.2018.03.054. Epub 2018 Mar 27.
In Luxembourg, a national Human Papillomavirus (HPV) vaccination programme was introduced in 2008, targeting 12-17 year old girls offering a choice of bivalent or quadrivalent vaccine free of charge. In 2015, the programme was changed offering the bivalent vaccine only to 11-13 year old girls. The aim of this study was to evaluate the HPV vaccination coverage, to assess the impact of age target changes and compare vaccination coverage to other European countries.
Anonymous HPV vaccination records consisting of individual vaccine doses obtained free of charge in pharmacies between 2008 and 2016 were extracted from the Luxembourgish Social Security database. Additional aggregate tables by nationality and municipality were analysed.
Of the target cohort of 39,610 girls born between 1991 and 2003 residing in Luxembourg, 24,550 (62.0%) subjects obtained at least one dose, 22,082 (55.7%) obtained at least two doses, and 17,197 (43.4%) obtained three doses of HPV vaccine. The mean age at first dose was 13.7 years during 2008-14 and 12.7 years in 2016 after the age target change. Coverage varied significantly by nationality (p < 0.0001): Portuguese (80%), former Yugoslavs (74%), Luxembourgish (54%), Belgian (52%), German (47%), French (39%) and other nationalities (51%). Coverage varied also by geographical region, with lower rates (<50%) noted in some Northern and Central areas of Luxembourg (range: 38% to 78%).
Overall HPV vaccination coverage in Luxembourg is moderate and varied by nationality and region. The policy changes in 2015 did not have a substantial impact except lowering age at initiating vaccination. Options to improve coverage deserve further investigation.
卢森堡于 2008 年推出了国家人乳头瘤病毒（HPV）疫苗接种计划，针对 12-17 岁女孩免费提供二价或四价疫苗。2015 年，该计划改为仅向 11-13 岁女孩提供二价疫苗。本研究旨在评估 HPV 疫苗接种覆盖率，评估年龄目标变化的影响，并与其他欧洲国家进行比较。
从卢森堡社会保险数据库中提取了 2008 年至 2016 年期间在药房免费获得的个人疫苗剂量的匿名 HPV 疫苗接种记录。按国籍和市分析了其他汇总表。
在卢森堡居住的 39610 名 1991 年至 2003 年出生的目标人群中，有 24550 名（62.0%）至少接种了一剂疫苗，22082 名（55.7%）至少接种了两剂疫苗，17197 名（43.4%）接种了三剂 HPV 疫苗。2008-14 年，首剂年龄的平均值为 13.7 岁，2016 年年龄目标改变后为 12.7 岁。覆盖率因国籍而异（p<0.0001）：葡萄牙人（80%）、前南斯拉夫人（74%）、卢森堡人（54%）、比利时人（52%）、德国人（47%）、法国人（39%）和其他国籍（51%）。覆盖率也因地理区域而异，卢森堡北部和中部一些地区的覆盖率较低（38%至 78%）。
卢森堡 HPV 疫苗接种覆盖率总体中等，因国籍和地区而异。2015 年的政策变化除了降低接种起始年龄外，没有产生实质性影响。进一步提高覆盖率的选择值得进一步调查。
