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J Glob Antimicrob Resist. 2018 Mar;12:185-186. doi: 10.1016/j.jgar.2018.01.021. Epub 2018 Feb 4.
2
Evaluation of the β-CARBA™ test, a colorimetric test for the rapid detection of carbapenemase activity in Gram-negative bacilli.β-CARBA™检测法的评估，一种用于快速检测革兰氏阴性杆菌中碳青霉烯酶活性的比色检测法。
J Antimicrob Chemother. 2017 Jun 1;72(6):1646-1658. doi: 10.1093/jac/dkx061.
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Modified Carba NP test for the detection of carbapenemase production in gram-negative rods: optimized handling of multiple samples.用于检测革兰氏阴性杆菌中产碳青霉烯酶的改良Carba NP试验：多个样本的优化处理
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Evaluation of phenotypic tests for detection of Klebsiella pneumoniae carbapenemase and metallo-beta-lactamase in clinical isolates of Escherichia coli and Klebsiella species.用于检测大肠埃希菌和克雷伯菌属临床分离株中肺炎克雷伯菌碳青霉烯酶和金属β-内酰胺酶的表型试验评估
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A disc diffusion assay for detection of class A, B and OXA-48 carbapenemases in Enterobacteriaceae using phenyl boronic acid, dipicolinic acid and temocillin.采用苯硼酸、二吡啶酸和替莫西林检测肠杆菌科中 A、B 和 OXA-48 碳青霉烯酶的纸片扩散法。
Clin Microbiol Infect. 2014 Apr;20(4):345-9. doi: 10.1111/1469-0691.12322. Epub 2013 Aug 9.
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A combined disk test for direct differentiation of carbapenemase-producing enterobacteriaceae in surveillance rectal swabs.联合磁盘试验可直接区分直肠拭子中耐碳青霉烯肠杆菌科的产酶株。
J Clin Microbiol. 2013 Sep;51(9):2986-90. doi: 10.1128/JCM.00901-13. Epub 2013 Jul 10.
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Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test.采用生化试验快速鉴定肠杆菌科和铜绿假单胞菌的碳青霉烯酶类型。
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改良碳青霉烯酶检测试验：鉴别产KPC酶和产金属β-内酰胺酶的克雷伯菌属细菌的简单快速方法。

Modified Carba NP Test: Simple and rapid method to differentiate KPC- and MBL-producing Klebsiella species.

作者信息

Kumar Nitin, Singh Varsha A, Beniwal Vikas, Pottathil Shinu

机构信息

M M Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.

Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India.

出版信息

J Clin Lab Anal. 2018 Sep;32(7):e22448. doi: 10.1002/jcla.22448. Epub 2018 Mar 30.

DOI:10.1002/jcla.22448
PMID:29603371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6817002/
Abstract

BACKGROUND

The aim of this study was to evaluate the modified Carba NP test to differentiate KPC (Klebsiella pneumoniae carbapenemase)- and MBL (metallo-β-lactamase)-producing Klebsiella species.

METHODS

A total of 508 non-duplicate clinical isolates of Klebsiella spp. were processed by modified Carba NP and combined disc tests which were further confirmed by conventional polymerase chain reaction (PCR), a gold standard method for statistical analysis.

RESULTS

Modified Carba NP test demonstrated 91.7% sensitivity, 100% specificity, 100% positive predictive value (PPV) and 99.8% negative predictive value (NPV) for KPC and 96.7%, 100%, 100%, and 99.5% for MBL detection, respectively.

CONCLUSION

The performance of modified Carba NP test was significantly better than combined disc test, fulfilling the requirement of simple and rapid test for clinical applications.

摘要

背景

本研究的目的是评估改良Carba NP试验，以区分产肺炎克雷伯菌碳青霉烯酶（KPC）和产金属β-内酰胺酶（MBL）的克雷伯菌属。

方法

共对508株非重复的克雷伯菌临床分离株进行改良Carba NP试验和复合纸片法检测，并通过传统聚合酶链反应（PCR）进一步确认，PCR是用于统计分析的金标准方法。

结果

改良Carba NP试验检测KPC的灵敏度为91.7%，特异性为100%，阳性预测值（PPV）为100%，阴性预测值（NPV）为99.8%；检测MBL的灵敏度、特异性、PPV和NPV分别为96.7%、100%、100%和99.5%。

结论

改良Carba NP试验的性能明显优于复合纸片法检测，满足临床应用中简单快速检测的要求。