系统评价评估了针对头颈部癌症和口腔发育不良患者的戒烟和戒酒干预的随机对照试验。
Systematic review evaluating randomized controlled trials of smoking and alcohol cessation interventions in people with head and neck cancer and oral dysplasia.
机构信息
National Institute for Health Research (NIHR), Bristol Biomedical Research Centre (BRC) Nutrition Theme, University of Bristol, Bristol, United Kingdom.
Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, United Kingdom.
出版信息
Head Neck. 2018 Aug;40(8):1845-1853. doi: 10.1002/hed.25138. Epub 2018 Mar 30.
BACKGROUND
Smoking and alcohol increase the risk of head and neck cancer and affect treatment outcomes. Interventions modifying these behaviors may improve posttreatment outcomes and survival. We systematically reviewed evidence of the effectiveness of smoking/alcohol interventions in head and neck cancer and oral dysplasia.
METHODS
The AMED, CINAHL, Embase, MEDLINE, and Web of Science databases were searched for randomized controlled trials (RCTs) of smoking/alcohol interventions in people with head and neck cancer. A qualitative synthesis of the studies was conducted.
RESULTS
Three RCTs were identified: 2 smoking interventions and 1 smoking and alcohol intervention. One intervention, which was comprised of a smoking intervention based on Cognitive Behavioral Therapy and pharmacologic management compared to usual care, reduced smoking prevalence.
CONCLUSION
Further research is required into the underlying mechanisms that lead to cessation and interventions that include both pharmacological and behavioral therapy. Future RCTs should include suitable control conditions and sufficient power to assess clinical outcomes.
背景
吸烟和饮酒会增加头颈部癌症的风险，并影响治疗效果。干预这些行为可能会改善治疗后的结果和生存。我们系统地回顾了吸烟/饮酒干预对头颈部癌症和口腔发育不良的有效性的证据。
方法
在 AMED、CINAHL、Embase、MEDLINE 和 Web of Science 数据库中搜索了针对头颈部癌症患者的吸烟/饮酒干预的随机对照试验 (RCT)。对研究进行了定性综合分析。
结果
确定了三项 RCT：2 项吸烟干预和 1 项吸烟和饮酒干预。一项干预措施由基于认知行为疗法和药物管理的吸烟干预与常规护理相比，降低了吸烟率。
结论
需要进一步研究导致戒烟的潜在机制，以及包括药物和行为治疗的干预措施。未来的 RCT 应包括合适的对照条件和足够的效力来评估临床结果。
Zotero 插件