Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Exp Dermatol. 2019 Oct;28(10):1135-1141. doi: 10.1111/exd.13550. Epub 2018 Jun 28.
Type XVII collagen (COL17) is a transmembranous protein that is mainly expressed in the epidermal basal keratinocytes. Epidermal-dermal attachment requires COL17 expression at the hemidesmosomes of the epidermal basement membrane zone because congenital COL17 deficiency leads to junctional epidermolysis bullosa and acquired autoimmunity to COL17 induces bullous pemphigoid. Recently, in addition to facilitating epidermal-dermal attachment, COL17 has been reported to serve as a niche for hair follicle stem cells, to regulate proliferation in the interfollicular epidermis and to be present along the non-hemidesmosomal plasma membrane of epidermal basal keratinocytes. This review focuses on the physiological properties of COL17 in the epidermis, its role in maintaining stem cells and its association with signalling pathways. We propose possible solutions to unanswered questions in this field.
XVII 型胶原（COL17）是一种跨膜蛋白，主要在表皮基底层角质形成细胞中表达。表皮-真皮附着需要 COL17 在表皮基底层质膜区的半桥粒中表达，因为先天性 COL17 缺乏会导致交界性大疱性表皮松解症，而获得性自身免疫 COL17 会引起大疱性类天疱疮。最近，除了促进表皮-真皮附着外，COL17 还被报道作为毛囊干细胞的龛位，调节毛囊间表皮的增殖，并存在于表皮基底层角质形成细胞的非半桥粒质膜上。这篇综述重点介绍了 COL17 在表皮中的生理特性，及其在维持干细胞中的作用及其与信号通路的关联。我们提出了该领域未解决问题的可能解决方案。
