欧洲预防阿尔茨海默病登记处：纵向队列和预防试验的招募和预筛选方法。
European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials.
机构信息
Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
Department of Genetics, University of Leicester, Leicester, UK.
出版信息
Alzheimers Dement. 2018 Jun;14(6):837-842. doi: 10.1016/j.jalz.2018.02.010. Epub 2018 Mar 28.
INTRODUCTION
It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.
METHODS
A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.
RESULTS
To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.
DISCUSSION
This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.
简介
在短时间内为阿尔茨海默病（AD）预防试验找到参与者是一项挑战。欧洲预防阿尔茨海默病痴呆登记处（EPAD）旨在通过从正在进行的队列研究中预先选择受试者来促进招募。本文介绍了这种新方法。
方法
建立了一个虚拟登记处，可以通过正在进行的队列研究的最小数据集访问 AD 的风险因素和生物标志物。
结果
迄今为止，已有 10 个队列被纳入 EPAD。使用与 AD 风险相关的变量，已从 EPAD 纵向队列研究中选择了大约 2500 名参与者，该研究作为一项试验准备队列。
讨论
本研究表明，虚拟登记处可用于 AD 研究参与者的预先选择。
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