Department of Neurobiology, Care Sciences, and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Theme Aging, Karolinska University Hospital, Huddinge, Sweden.
BMC Geriatr. 2020 Mar 6;20(1):93. doi: 10.1186/s12877-020-1478-3.
There remains a lack of large-scale clinical studies of cognitive impairment that aim to increase diagnostic and prognostic accuracy as well as validate previous research findings. The MemClin project will amass large quantities of cross-disciplinary data allowing for the construction of robust models to improve diagnostic accuracy, expand our knowledge on differential diagnostics, strengthen longitudinal prognosis, and harmonise examination protocols across centres. The current article describes the Memory Clinic (MemClin) project's study-design, materials and methods, and patient characteristics. In addition, we present preliminary descriptive data from the ongoing data collection.
Nine out of ten memory clinics in the greater Stockholm area, which largely use the same examination methods, are included. The data collection of patients with different stages of cognitive impairment and dementia is coordinated centrally allowing for efficient and secure large-scale database construction. The MemClin project rest directly on the memory clinics examinations with cognitive measures, health parameters, and biomarkers.
Currently, the MemClin project has informed consent from 1543 patients. Herein, we present preliminary data from 835 patients with confirmed cognitive diagnosis and neuropsychological test data available. Of those, 239 had dementia, 487 mild cognitive impairment (MCI), and 104 subjective cognitive impairment (SCI). In addition, we present descriptive data on visual ratings of brain atrophy and cerebrospinal fluid markers.
Based on our current progress and preliminary data, the MemClin project has a high potential to provide a large-scale database of 1200-1500 new patients annually. This coordinated data collection will allow for the construction of improved diagnostic and prognostic models for neurodegenerative disorders and other cognitive conditions in their naturalistic setting.
目前仍缺乏旨在提高诊断和预后准确性以及验证先前研究结果的大规模认知障碍临床研究。MemClin 项目将汇集大量跨学科数据，构建稳健的模型，以提高诊断准确性，扩展我们对鉴别诊断的认识，加强纵向预后，并协调各中心的检查方案。本文描述了记忆诊所（MemClin）项目的研究设计、材料和方法以及患者特征。此外，我们还展示了正在进行的数据收集的初步描述性数据。
包括斯德哥尔摩大都市区的 10 家记忆诊所中的 9 家，这些诊所主要使用相同的检查方法。不同认知障碍和痴呆阶段的患者数据的收集由中央协调，从而能够有效地构建安全的大规模数据库。MemClin 项目直接建立在记忆诊所的检查基础上，包括认知措施、健康参数和生物标志物。
目前，MemClin 项目已获得 1543 名患者的知情同意。在此，我们从 835 名已确诊认知障碍且具有神经心理学测试数据的患者中呈现初步数据。其中，239 名患者患有痴呆症，487 名患者患有轻度认知障碍（MCI），104 名患者患有主观认知障碍（SCI）。此外，我们还呈现了大脑萎缩的视觉评分和脑脊液标志物的描述性数据。
基于我们目前的进展和初步数据，MemClin 项目有很高的潜力每年提供 1200-1500 名新患者的大型数据库。这种协调的数据收集将允许在自然环境中构建用于神经退行性疾病和其他认知障碍的改进诊断和预后模型。
