母亲孕期吸烟与后代小儿心血管疾病风险：一项长达 18 年随访的基于人群的队列研究。
Maternal smoking during pregnancy and the risk of pediatric cardiovascular diseases of the offspring: A population-based cohort study with up to 18-years of follow up.
机构信息
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Reprod Toxicol. 2018 Jun;78:69-74. doi: 10.1016/j.reprotox.2018.03.009. Epub 2018 Mar 28.
BACKGROUND
Cigarette smoke is a well-known reproductive toxicant. We aimed to study the long-term effect of cigarette smoking during pregnancy on the risk for childhood cardiovascular morbidity of the offspring.
METHODS
A population-based cohort analysis was performed comparing total and subtypes of cardiovascular related pediatric hospitalizations among offspring of smoking mothers versus offspring of non-smoking mothers. The analysis included all singletons born between the years 1999-2014.A Kaplan-Meier survival curve was used to compare the cumulative cardiovascular morbidity, and a Cox proportional hazards model was constructed to adjust for confounders.
RESULTS
The study population included 242,342 newborns which met inclusion criteria; among them 2861 were born to smoking mothers. Offspring of smoking mothers had higher rates of cardiovascular-related hospitalizations (1.3% vs. 0.6%, OR 2.1, 95% CI 1.5-2.9; p < 0.001; Kaplan-Meier log-rank test p < 0.001).
CONCLUSION
Smoking exposure during pregnancy is associated with an increased risk for long-term pediatric cardiovascular morbidity of the offspring.
背景
香烟烟雾是一种众所周知的生殖毒物。我们旨在研究怀孕期间吸烟对后代儿童心血管发病率的长期影响。
方法
进行了一项基于人群的队列分析，比较了吸烟母亲和不吸烟母亲的后代中总心血管相关和亚型儿科住院率。该分析包括了 1999 年至 2014 年之间所有的单胎新生儿。使用 Kaplan-Meier 生存曲线比较累积心血管发病率，并构建 Cox 比例风险模型以调整混杂因素。
结果
研究人群包括符合纳入标准的 242342 名新生儿；其中 2861 名新生儿的母亲吸烟。吸烟母亲的后代心血管相关住院率更高（1.3%比 0.6%，OR 2.1，95%CI 1.5-2.9；p<0.001；Kaplan-Meier 对数秩检验 p<0.001）。
结论
怀孕期间吸烟暴露与后代长期儿科心血管发病率增加有关。
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