Department of Psychology, University of Rhode Island, USA.
Department of Psychology, University of Rhode Island, USA.
J Adolesc. 2018 Jun;65:177-188. doi: 10.1016/j.adolescence.2018.03.013. Epub 2018 Mar 28.
The prevalence of marijuana use among adolescents with anxiety disorders in the USA is markedly high and well documented; however, the literature on this co-occurrence's effect on adolescent brain development and functioning is limited. This systematic review searched six databases to 1) explore the literature concerning marijuana use among adolescents with anxiety and 2) examine the effects of marijuana on brain structure and functioning. Overall, 27 studies from six countries were included in this review. Out of these studies, several disparate designs were utilized. The majority of studies revealed an association between marijuana use and anxiety, but the strength of the association and the variability among the studies' designs limited the comparison and warrants additional investigation. Only five studies met criteria that used brain-imaging techniques, and findings were non-conclusive. Future evaluations should further investigate the effects of co-occurring marijuana use and anxiety disorders on brain structure and functioning among adolescents.
美国焦虑障碍青少年中大麻使用的流行率明显很高，并有充分的文献记载；然而，关于这种共病对青少年大脑发育和功能影响的文献有限。本系统综述检索了六个数据库，旨在 1）探讨有关焦虑青少年大麻使用的文献，以及 2）研究大麻对大脑结构和功能的影响。总的来说，本综述纳入了来自六个国家的 27 项研究。在这些研究中，使用了几种不同的设计。大多数研究表明大麻使用与焦虑之间存在关联，但关联的强度以及研究设计的差异限制了比较，需要进一步的研究。只有五项研究符合使用脑成像技术的标准，但结果尚无定论。未来的评估应进一步研究共病大麻使用和焦虑障碍对青少年大脑结构和功能的影响。
