Chen Fengyuan, Sun Hao, Zhao Yu, Wang Huating
Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China; Department of Chemical Pathology, Chinese University of Hong Kong, Hong Kong, China.
Department of Orthopaedics and Traumotologya, Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.
Crit Rev Oncog. 2017;22(1-2):131-141. doi: 10.1615/CritRevOncog.2017021311.
Yin Yang1 (YY1) is a ubiquitous expressed transcription factor that modulates a variety of biologic processes with prominent roles in cellular differentiation and tissue development. Recent advances in molecular biology, mouse genetics, and particularly high-throughput sequencing have greatly enhanced our understanding of YY1 functions and underlying mechanisms in regulating transcription and epigenetics. In this review, we summarize findings on the roles of YY1 in cell differentiation and tissue development, in particular in muscle, nerve, and immune cells/tissues.
阴阳1（YY1）是一种广泛表达的转录因子，它调节多种生物学过程，在细胞分化和组织发育中发挥着重要作用。分子生物学、小鼠遗传学，尤其是高通量测序方面的最新进展，极大地增进了我们对YY1在调节转录和表观遗传学中的功能及潜在机制的理解。在这篇综述中，我们总结了YY1在细胞分化和组织发育，特别是在肌肉、神经和免疫细胞/组织中的作用的研究发现。
