Kleinhans Kelsey L, Jackson Alicia R
Orthopaedic Biomechanics Laboratory, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA.
Orthopaedic Biomechanics Laboratory, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA.
J Biomech. 2018 Apr 27;72:215-221. doi: 10.1016/j.jbiomech.2018.03.011. Epub 2018 Mar 16.
Hydraulic permeability is an important material property of cartilaginous tissues, governing the rate of fluid flow, which is crucial to tissue biomechanics and cellular nutrition. The effects of strain, anisotropy, and region on the hydraulic permeability in meniscus tissue have not been fully elucidated. Using a one-dimensional direct permeation test, we measured the hydraulic permeability within statically compressed porcine meniscus specimens, prepared such that the explants were in either the axial or circumferential direction of either the central or horn (axial direction only) region of the medial and lateral menisci. A constant flow was applied and the pressure difference was measured using pressure transducers. Specimens were tested under 10-20% compressive strain. Permeability values were in the range of 1.53-1.87 × 10 m/Ns, which is comparable to values found in the literature. Permeability was significantly anisotropic, being higher in the circumferential direction than in the axial direction. Additionally, there was a significant negative correlation between strain level and permeability for all groups. Lastly, no statistically significant difference was found between permeability coefficients from different regional locations. This study provides important information regarding structure-function relationships in meniscal tissues that helps to elucidate biomechanics and transport in the tissue, and can aid in the understanding of the tissue's role in the function of the knee joint and onset of osteoarthritis.
水力渗透性是软骨组织的一项重要材料特性，它决定了流体流动的速率，而流体流动速率对组织生物力学和细胞营养至关重要。应变、各向异性和区域对半月板组织水力渗透性的影响尚未完全阐明。我们采用一维直接渗透试验，测量了静态压缩猪半月板标本的水力渗透性，所制备的外植体分别处于内侧和外侧半月板中央或角部（仅轴向）区域的轴向或周向。施加恒定流量，并使用压力传感器测量压力差。在10% - 20%的压缩应变下对标本进行测试。渗透值在1.53 - 1.87×10⁻¹⁴m²/Ns范围内，这与文献中报道的值相当。渗透性具有显著的各向异性，周向的渗透性高于轴向。此外，所有组的应变水平与渗透性之间存在显著的负相关。最后，不同区域位置的渗透系数之间未发现统计学上的显著差异。本研究提供了有关半月板组织结构 - 功能关系的重要信息，有助于阐明组织中的生物力学和物质传输，并有助于理解该组织在膝关节功能和骨关节炎发病中的作用。
