青少年与年轻成人弥漫性大 B 细胞淋巴瘤的临床特征与预后
Clinical characteristics and outcomes of diffuse large B-cell lymphoma in adolescents and young adults.
机构信息
Department of Hematology, National Hospital Organization Nagoya Medical Center, 4-1-1, Sannomaru, Naka-ku, Nagoya, 460-0001, Japan.
Department of Hematology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
出版信息
Int J Hematol. 2018 Aug;108(2):161-166. doi: 10.1007/s12185-018-2449-8. Epub 2018 Mar 31.
Clinical information regarding non-Hodgkin lymphoma (NHL) in adolescents and young adults (AYA) is lacking. We retrospectively analyzed 1426 consecutively registered patients with newly diagnosed NHL. Of 798 DLBCL patients, 42 (5.3%) were identified as AYA (16-39 years). The characteristics of AYA DLBCL patients showed no significant differences compared to older adult DLBCL patients (age ≥ 40 years). Progression-free survival (PFS) and overall survival (OS) in AYA were similar to those in patients aged 40-60 years. However, in older adult groups, PFS and OS were significantly different according to the age group (40-60, 61-79, and ≥ 80 years). In univariate analysis in AYA, performance status, clinical stage, International Prognostic Index (IPI), and age-adjusted IPI significantly affected both PFS and OS. In multivariate analysis, only clinical stage was identified as an independent predictor among AYA. In conclusion, disease characteristics and outcomes of DLBCL in AYA were nearly the same as those in older adults.
青少年和年轻成人（AYA）非霍奇金淋巴瘤（NHL）的临床信息较少。我们回顾性分析了 1426 例连续登记的新诊断 NHL 患者。在 798 例弥漫性大 B 细胞淋巴瘤（DLBCL）患者中，有 42 例（5.3%）被确定为 AYA（16-39 岁）。与年龄较大的成人 DLBCL 患者相比，AYA DLBCL 患者的特征没有显著差异（年龄≥40 岁）。AYA 的无进展生存期（PFS）和总生存期（OS）与 40-60 岁患者相似。然而，在老年组中，PFS 和 OS 根据年龄组（40-60、61-79 和≥80 岁）有显著差异。在 AYA 的单因素分析中，体能状态、临床分期、国际预后指数（IPI）和年龄调整后的 IPI 显著影响 PFS 和 OS。在多因素分析中，仅临床分期被确定为 AYA 的独立预测因素。总之，AYA 的 DLBCL 疾病特征和结局与成年人相似。
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