Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA.
Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA.
Trends Endocrinol Metab. 2018 May;29(5):349-359. doi: 10.1016/j.tem.2018.03.002. Epub 2018 Mar 29.
Human stem cell-based models of thermogenic adipocytes provide an opportunity for the establishment of new therapeutics, modeling of disease mechanisms, and understanding of development. Pluripotent stem cells, adipose-derived stem cells/preadipocytes, and programming-reprogramming-based approaches have been used to develop cell-based platforms for drug screening and transplantable therapeutics in the metabolic disease arena. Here we provide a detailed overview of these approaches, the latest advances in this field, and the opportunities and shortcomings they present. Moreover, we comment on how stem-cell-based platforms can be best utilized in the future for the treatment and understanding of metabolic diseases, including type 2 diabetes and associated medical issues such as obesity.
基于人类干细胞的产热脂肪细胞模型为新疗法的建立、疾病机制的建模以及发育的理解提供了机会。多能干细胞、脂肪来源的干细胞/前体细胞和基于编程重编程的方法已被用于开发用于药物筛选和代谢疾病领域可移植治疗的基于细胞的平台。在这里，我们详细概述了这些方法、该领域的最新进展以及它们所带来的机会和缺点。此外，我们还评论了基于干细胞的平台如何在未来最好地用于治疗和理解代谢疾病，包括 2 型糖尿病和肥胖等相关医学问题。
