Department of nuclear medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Endocrinology, Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne). 2022 May 4;13:884944. doi: 10.3389/fendo.2022.884944. eCollection 2022.
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity). It could be the origin of various metabolic disorders including hypertension, hyperlipidemia, type 2 diabetes, cardiovascular diseases etc. Active adipose tissue was discovered in humans through F-fluorodeoxyglucose Positron Emission Tomography coupled with Computer Tomography (F FDG-PET/CT), which was initially performed for tumor scanning. Since human active adipose tissue is probably composed of brown and beige adipose tissues and they burn white adipose tissue to generate heat, targeting human brown/beige adipose tissue to induce their thermogenic function is considered significant to combat obesity. In this review, we describe the latest advancements on promising therapeutic strategies to combat obesity by targeting human thermogenic adipose tissues to achieve further metabolic balance in humans.
肥胖被定义为体内白色脂肪组织过度积累，主要在皮下（皮下脂肪过多）或腹腔内（内脏脂肪过多）。它可能是包括高血压、高血脂、2 型糖尿病、心血管疾病等各种代谢紊乱的根源。通过 F-氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描（F FDG-PET/CT），人类首次发现了活跃的脂肪组织，该技术最初用于肿瘤扫描。由于人类活跃的脂肪组织可能由棕色和米色脂肪组织组成，它们通过燃烧白色脂肪组织来产生热量，因此靶向人类棕色/米色脂肪组织来诱导其产热功能被认为对对抗肥胖具有重要意义。在这篇综述中，我们描述了通过靶向人类产热脂肪组织来对抗肥胖的有前途的治疗策略的最新进展，以实现人类的进一步代谢平衡。
