Department of Exercise Physiology, School of Physical Education and Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran.
Neurophysiol Clin. 2018 Sep;48(4):195-202. doi: 10.1016/j.neucli.2018.03.001. Epub 2018 Mar 30.
Peripheral neuropathy (PN) is one of the long-term complications of diabetes. Few studies have investigated the role of regular exercise on diabetic PN. We examined the effect of aerobic training on nerve conduction velocity and action potential amplitude in the lower limbs of men with type 2 diabetes and PN.
In a randomized controlled study, 24 volunteers diagnosed with diabetic PN were randomly assigned to exercise or control groups. Aerobic training consisted of 20-45min walking or running at 50-70% of heart rate reserve for three sessions per week over 12weeks. Before and 48h after the experimental period, nerve conduction studies were performed and blood samples were taken to be analyzed for HbA1c, fasting and 2h postprandial glucose concentration. Data were analyzed using repeated-measures ANOVA at significance level of P<0.05.
Sural sensory nerve conduction velocity (NCV) in the exercise group significantly increased (from 35.2±4.3m/s to 37.3±6.2m/s) compared to the control group (P=0.007). Changes in peroneal and tibial motor NCV and nerve action potential amplitude (NAPA) in all nerves studied were not different between groups (P>0.05). Moreover, HbA1c decreased to a greater extent in the exercise group compared to the control (P=0.014).
Aerobic exercise training may have the potential to hinder the progression of diabetic PN by improving NCV. Given the sparse evidence in this domain, exercise-related mechanisms need to be studied in the future.
周围神经病变（PN）是糖尿病的长期并发症之一。很少有研究调查规律运动对糖尿病性 PN 的作用。我们研究了有氧运动对 2 型糖尿病合并周围神经病变男性下肢神经传导速度和动作电位幅度的影响。
在一项随机对照研究中，24 名被诊断为糖尿病性周围神经病变的志愿者被随机分为运动组和对照组。有氧运动包括每周 3 次，每次 20-45 分钟，以 50-70%的心率储备进行步行或跑步。在实验期间前后 48 小时，进行神经传导研究，并采集血液样本以分析糖化血红蛋白、空腹和餐后 2 小时血糖浓度。数据采用重复测量方差分析，显著性水平为 P<0.05。
与对照组相比，运动组的腓肠感觉神经传导速度（NCV）明显增加（从 35.2±4.3m/s 增加到 37.3±6.2m/s，P=0.007）。研究中所有神经的腓总神经和胫神经运动 NCV 和神经动作电位幅度（NAPA）的变化在组间无差异（P>0.05）。此外，与对照组相比，运动组的糖化血红蛋白降低幅度更大（P=0.014）。
有氧运动训练可能通过改善 NCV 来阻止糖尿病性周围神经病变的进展。鉴于该领域证据不足，需要进一步研究与运动相关的机制。
