Ortiz A, Pohl R, Gershon S
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI.
J Affect Disord. 1987 Sep-Oct;13(2):131-43. doi: 10.1016/0165-0327(87)90018-8.
Buspirone is a new anxiolytic that is structurally unrelated to other psychotropic drugs. The drug is as effective as benzodiazepines for the treatment of generalized anxiety, and superior to placebo. The effect of buspirone on other anxiety disorders, such as panic disorder or post-traumatic stress disorder, remains untested. Although buspirone's mechanism of action is unknown, it clearly does not act on the same receptor systems that are affected by benzodiazepines. Buspirone appears to lack dependence and abuse potential and has little or no sedative effect. In addition, the drug does not potentiate sedative-hypnotic drugs and does not potentiate functional impairment produced by alcohol. Like benzodiazepines, buspirone appears to be safe even when given in very high doses.
丁螺环酮是一种新型抗焦虑药，其结构与其他精神药物无关。该药物在治疗广泛性焦虑方面与苯二氮䓬类药物效果相当，且优于安慰剂。丁螺环酮对其他焦虑症，如惊恐障碍或创伤后应激障碍的疗效仍未得到验证。尽管丁螺环酮的作用机制尚不清楚，但它显然不会作用于受苯二氮䓬类药物影响的相同受体系统。丁螺环酮似乎没有依赖性和滥用潜力，几乎没有或没有镇静作用。此外，该药物不会增强镇静催眠药物的作用，也不会增强酒精引起的功能损害。与苯二氮䓬类药物一样，即使大剂量服用丁螺环酮似乎也是安全的。
