Faludi G
Semmelweis Orvostudományi Egyetem, Psychiatriai és Psychotherapiás Klinika, Budapest.
Orv Hetil. 1994 Aug 14;135(33):1807-13.
Buspiron an azaspirodecanedione, heterocyclic compound which, although structurally unrelated to the benzodiazepines, possesses comparable anxiolytic activity. Because buspirone lacks hypnotic, anticonvulsant and muscle relaxant properties, it has been termed "anxioselective". It seems unlikely to generate the problems of dependence, abuse and rebound. It does not impair psychomotor or cognitive performance and appears to have no additive effect with other CNS-active agents, particularly alcohol. Clinical trials and studies of buspiron suggest that it is an effective treatment for the relief of symptoms of anxiety, especially in patients in whom daytime alertness is particularly important.
丁螺环酮是一种氮杂螺癸二酮类杂环化合物，尽管其结构与苯二氮䓬类无关，但具有类似的抗焦虑活性。由于丁螺环酮缺乏催眠、抗惊厥和肌肉松弛特性，它被称为“抗焦虑选择性药物”。它似乎不太可能产生依赖、滥用和戒断反应问题。它不会损害精神运动或认知功能，并且与其他中枢神经系统活性药物，尤其是酒精，似乎没有相加作用。丁螺环酮的临床试验和研究表明，它是缓解焦虑症状的有效治疗药物，特别是对白天警觉性特别重要的患者。
