a Department of Urology , Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University , Nanjing , P. R. China.
Artif Cells Nanomed Biotechnol. 2018;46(sup2):356-363. doi: 10.1080/21691401.2018.1457536. Epub 2018 Apr 1.
Cisplatin is widely used in cancer treatment, but the application is limited due to toxicities and its acquired resistance. In this study, we delivered cisplatin to prostate cancer cells by linking the platinum prodrug Pt(IV) to melanin-like nanoparticles (MeNPs), a promising photothermal therapeutic agent with excellent biocompatibility. As expected, the Pt(IV)-MeNPs exhibited brilliant synergic photothermal-chemotherapy upon near-infrared reflection exposure. Compared with free cisplatin, Pt(IV)-MeNPs displayed highly effective antitumour activity both in vitro and in vivo.
顺铂被广泛应用于癌症治疗，但由于其毒性和获得性耐药性，其应用受到限制。在这项研究中，我们通过将顺铂前药 Pt(IV)与黑色素样纳米粒子（MeNPs）连接，将顺铂递送至前列腺癌细胞中，MeNPs 是一种具有优异生物相容性的很有前途的光热治疗剂。正如预期的那样，Pt(IV)-MeNPs 在近红外反射照射下表现出出色的协同光热化疗作用。与游离顺铂相比，Pt(IV)-MeNPs 在体外和体内均显示出高效的抗肿瘤活性。
