Ferroni Claudia, Del Rio Alberto, Martini Cecilia, Manoni Elisabetta, Varchi Greta
Institute of Organic Synthesis and Photoreactivity - ISOF, Italian National Research Council, Bologna, Italy.
Innovamol Consulting Srl, Modena, Italy.
Front Chem. 2019 Oct 29;7:719. doi: 10.3389/fchem.2019.00719. eCollection 2019.
Prostate cancer (PC) is one of the most widespread tumors affecting the urinary system and the fifth-leading cause from cancer death in men worldwide. Despite PC mortality rates have been decreasing during the last years, most likely due to an intensification of early diagnosis, still more than 300,000 men die each year because of this disease. In this view, researchers in all countries are engaged in finding new ways to tackle PC, including the design and synthesis of novel molecular and macromolecular entities able to challenge different PC biological targets, while limiting the extent of unwanted side effects that significantly limit men's life quality. Among this field of research, photo-induced therapies, such as photodynamic and photothermal therapies (PDT and PTT), might represent an important advancement in PC treatment due to their extremely localized and controlled cytotoxic effect, as well as their low incidence of side effects and tumor resistance occurrence. Based on these considerations, this review aims to gather and discuss the last 5-years literature reports dealing with the synthesis and biological activity of molecular conjugates and nano-platforms for photo-induced therapies as co-adjuvant or combined therapeutic modalities for the treatment of localized PC.
前列腺癌（PC）是影响泌尿系统的最常见肿瘤之一，也是全球男性癌症死亡的第五大原因。尽管近年来前列腺癌死亡率有所下降，这很可能是由于早期诊断的强化，但每年仍有超过30万男性死于这种疾病。有鉴于此，各国研究人员都在致力于寻找应对前列腺癌的新方法，包括设计和合成能够挑战不同前列腺癌生物学靶点的新型分子和大分子实体，同时限制会显著影响男性生活质量的不良副作用的程度。在这一研究领域中，光诱导疗法，如光动力疗法和光热疗法（PDT和PTT），可能代表了前列腺癌治疗的一项重要进展，因为它们具有极其局部化和可控的细胞毒性作用，以及较低的副作用发生率和肿瘤耐药性发生率。基于这些考虑，本综述旨在收集和讨论过去5年中有关用于光诱导疗法的分子缀合物和纳米平台的合成及生物活性的文献报道，这些疗法作为辅助或联合治疗方式用于治疗局限性前列腺癌。
