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假性痛风——甲状旁腺聚焦切除术后饥饿骨综合征的罕见表现。

Pseudogout - a rare manifestation of hungry bone syndrome after focused parathyroidectomy.

作者信息

Tai C H, Oh H B, Seet J E, Ngiam K Y

机构信息

Division of General Surgery (Thyroid and Endocrine Surgery), University Surgical Cluster, Department of Surgery, National University Health System , Singapore.

Department of Pathology, National University Health System , Singapore.

出版信息

Ann R Coll Surg Engl. 2018 May;100(5):e106-e108. doi: 10.1308/rcsann.2018.0028. Epub 2018 Apr 1.

Abstract

Pseudogout, also known as calcium pyrophosphate deposition disease, is a rheumatological condition arising from accumulation of calcium pyrophosphate dihydrate crystals in connective tissues. We present a case of a 56-year-old Bangladeshi woman who underwent focused right inferior parathyroidectomy for primary hyperparathyroidism from a right inferior parathyroid adenoma. On the first post-operative day, she complained of left elbow painful swelling with redness and warmth. Arthrocentesis of left elbow was done due to suspicion of septic arthritis. Two weeks prior to this surgery, she had sudden bilateral knee swelling was diagnosed in her home country of bilateral knee osteoarthritis with effusion and arthrocentesis showed no crystals. Aspiration of left elbow showed calcium pyrophosphate crystals, associated with post parathyroidectomy hypocalcemia, hypomagnesemia confirming pseudogout. Her uric acid level was normal. Bilateral wrist x-rays showed triangular fibrocartilage complex chondrocalcinosis. The patient's condition improved with colchicine and naproxen, as well as calcium and magnesium replacement. Her left elbow swelling and pain resolved. Pseudogout flare is a rare but known sequelae after parathyroidectomy. Early recognition and expeditious treatment is essential.

摘要

假性痛风,又称焦磷酸钙沉积病,是一种由于二水焦磷酸钙晶体在结缔组织中积聚而引起的风湿性疾病。我们报告一例56岁的孟加拉国女性病例,该患者因右下甲状旁腺腺瘤导致原发性甲状旁腺功能亢进,接受了右下甲状旁腺切除术。术后第一天,她主诉左肘疼痛肿胀,伴有发红和发热。因怀疑为化脓性关节炎,对左肘进行了关节穿刺。在此次手术前两周,她在家乡突然出现双侧膝关节肿胀,被诊断为双侧膝关节骨关节炎伴积液,关节穿刺未发现晶体。左肘穿刺显示有焦磷酸钙晶体,伴有甲状旁腺切除术后低钙血症、低镁血症,确诊为假性痛风。她的尿酸水平正常。双侧腕部X线片显示三角纤维软骨复合体软骨钙质沉着症。患者使用秋水仙碱和萘普生以及补充钙和镁后病情好转。她左肘的肿胀和疼痛消失。假性痛风发作是甲状旁腺切除术后一种罕见但已知的后遗症。早期识别和迅速治疗至关重要。

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