Bennett R M, Lehr J R, McCarty D J
Arthritis Rheum. 1976 Jan-Feb;19(1):93-7. doi: 10.1002/art.1780190116.
Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
四名患有膝关节软骨钙质沉着症的患者自愿接受关节灌洗。初步实验表明，乙二胺四乙酸二钠和镁离子是焦磷酸钙双水合物（CPPD）晶体的有效增溶剂。该 procedure 在治疗上是失败的，因为去除的 CPPD 量极少，且所有 4 名受试者在灌洗后都出现了假性痛风发作。据推测，假性痛风的急性发作是晶体脱落的结果，可能由任何增强 CPPD 溶解度的因素触发。
