晶体脱落与急性假性痛风。基于一次治疗失败的假说。

Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.

作者信息

Bennett R M, Lehr J R, McCarty D J

出版信息

Arthritis Rheum. 1976 Jan-Feb;19(1):93-7. doi: 10.1002/art.1780190116.

DOI:10.1002/art.1780190116

Abstract

Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.

摘要

四名患有膝关节软骨钙质沉着症的患者自愿接受关节灌洗。初步实验表明，乙二胺四乙酸二钠和镁离子是焦磷酸钙双水合物（CPPD）晶体的有效增溶剂。该 procedure 在治疗上是失败的，因为去除的 CPPD 量极少，且所有 4 名受试者在灌洗后都出现了假性痛风发作。据推测，假性痛风的急性发作是晶体脱落的结果，可能由任何增强 CPPD 溶解度的因素触发。