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在肝硬化中,问题是要盐还是不要盐?

To salt or not to salt?-That is the question in cirrhosis.

机构信息

Clinical Medical Nutrition Therapy, University Hospital Graz, Graz, Austria.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

出版信息

Liver Int. 2018 Jul;38(7):1148-1159. doi: 10.1111/liv.13750. Epub 2018 May 16.

Abstract

Ascites is the most common complication of patients with cirrhosis, resulting from portal hypertension and vasodilatation. It is associated with an increased risk for the development of hyponatraemia and renal failure and has a high mortality rate of 20% per year. The development of ascites represents a baleful sign in the course of disease in cirrhosis. To prevent complications of cirrhosis and improve quality of life, an effective management of ascites is pivotal. Combined salt restriction and diuretic therapy is recommended as first-line therapy in numerous clinical practice guidelines. In contrast, there has been a debate on whether a strict salt-restricted diet for cirrhosis patients should be used at all since salt restriction may increase the risk for malnutrition which in turn may negatively impact on quality of life and survival. This review aims to summarize the current pros and cons regarding salt restriction in patients with cirrhosis and proposes the importance of achieving a sodium balance throughout different stages of cirrhosis.

摘要

腹水是肝硬化患者最常见的并发症,由门静脉高压和血管扩张引起。它与低钠血症和肾衰竭的发展风险增加相关,年死亡率高达 20%。腹水的发展是肝硬化病程中的一个不利标志。为了预防肝硬化并发症并提高生活质量,腹水的有效管理至关重要。在许多临床实践指南中,联合盐限制和利尿剂治疗被推荐为一线治疗。相比之下,对于肝硬化患者是否应该进行严格的低盐饮食一直存在争议,因为盐限制可能会增加营养不良的风险,而营养不良反过来又可能对生活质量和生存产生负面影响。本综述旨在总结目前关于肝硬化患者盐限制的利弊,并提出在肝硬化的不同阶段实现钠平衡的重要性。

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