Tarleton R L, Scott D W
Department of Zoology, University of Georgia, Athens 30602.
Parasite Immunol. 1987 Sep;9(5):579-89. doi: 10.1111/j.1365-3024.1987.tb00531.x.
Infection of a relatively resistant strain of mice (C57BL/6J) with the protozoan parasite Trypanosoma cruzi results in both the induction of parasite-specific T-helper cells and nonspecific suppressor cells. A time course study of the activation of help and suppression revealed that parasite-specific T-helper cell activity increases very early in infection (less than 12 days) at a time when suppression of non-parasite-specific responses and suppressor cell activity is increasing. Between 12 and 14 days of infection, the T-helper cell response to T. cruzi, as measured by the antibody response to hapten-T. cruzi in vitro, is suddenly and dramatically regulated. As reported previously, plastic and G-10 adherent cells appear to be responsible for the regulation of antibody responses to heterologous antigen during T. cruzi infection. These adherent suppressor cells are also responsible for the suppression of antibody responses to hapten-T. cruzi following the first 2 weeks of infection. Suppressor cells continue to regulate the parasite-specific response well into chronic infection even though the response to hapten-T. cruzi appears to return to normal levels. These results are the first to directly implicate nonspecific suppressor cells in the regulation of anti-T. cruzi humoral immune responses.
用原生动物寄生虫克氏锥虫感染相对具有抗性的小鼠品系（C57BL/6J），会诱导产生寄生虫特异性T辅助细胞和非特异性抑制细胞。对辅助和抑制激活的时间进程研究表明，寄生虫特异性T辅助细胞活性在感染早期（不到12天）就会增加，此时非寄生虫特异性反应的抑制和抑制细胞活性正在增强。在感染的第12天至14天之间，通过体外对半抗原 - 克氏锥虫的抗体反应来衡量，T辅助细胞对克氏锥虫的反应会突然且显著地受到调节。如先前报道，塑料贴壁细胞和G - 10贴壁细胞似乎在克氏锥虫感染期间负责调节对异源抗原的抗体反应。这些贴壁抑制细胞也负责在感染的前两周后抑制对半抗原 - 克氏锥虫的抗体反应。即使对半抗原 - 克氏锥虫的反应似乎恢复到正常水平，抑制细胞在慢性感染期间仍继续很好地调节寄生虫特异性反应。这些结果首次直接表明非特异性抑制细胞参与了抗克氏锥虫体液免疫反应的调节。
