Choromanski L, Kuhn R E
Infect Immun. 1987 Feb;55(2):403-8. doi: 10.1128/iai.55.2.403-408.1987.
Mice infected with Trypanosoma cruzi exhibit an early and profound suppression of parasite-specific and nonspecific immune responses. Earlier studies have shown that this suppression is due, at least in part, to suppressor macrophages, deficiency in production of interleukin-2 (IL-2), and reduced T helper (Th)-cell activity. In the present study, the effect of exogenously supplied IL-2 on enhancement of parasite-specific Th-cell activity, anti-parasite immunoglobulin G (IgG) and IgM antibody levels, parasitemia, and longevity was examined in infected mice. The results showed that administration of IL-2 with and without antigenic stimulation with trinitrophenylated T. cruzi significantly enhanced parasite-specific IgM and IgG levels. Injection of IL-2 and trinitrophenylated T. cruzi together significantly enhanced parasite-specific Th-cell activity and was more effective in enhancement of parasite-specific antibody levels. In addition, it was found that IL-2 alone had a rapid and lasting effect in reducing parasitemia. These results suggest that deficiency in IL-2 may play a major role in host susceptibility to T. cruzi.
感染克氏锥虫的小鼠表现出对寄生虫特异性和非特异性免疫反应的早期且显著的抑制。早期研究表明，这种抑制至少部分归因于抑制性巨噬细胞、白细胞介素-2（IL-2）产生不足以及T辅助（Th）细胞活性降低。在本研究中，检测了外源性提供的IL-2对感染小鼠中寄生虫特异性Th细胞活性增强、抗寄生虫免疫球蛋白G（IgG）和IgM抗体水平、寄生虫血症及寿命的影响。结果显示，无论有无用三硝基苯化克氏锥虫进行抗原刺激，给予IL-2均显著提高了寄生虫特异性IgM和IgG水平。同时注射IL-2和三硝基苯化克氏锥虫显著增强了寄生虫特异性Th细胞活性，并且在提高寄生虫特异性抗体水平方面更有效。此外，发现单独使用IL-2在降低寄生虫血症方面具有快速且持久的作用。这些结果表明，IL-2缺乏可能在宿主对克氏锥虫的易感性中起主要作用。
