Sayari Saba, Molaei Ziba, Torabi Zohre
Zanjan University of Medical Sciences, Zanjan, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Pediatrics, Ayatollah Moussavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Ann Pediatr Endocrinol Metab. 2018 Mar;23(1):38-42. doi: 10.6065/apem.2018.23.1.38. Epub 2018 Mar 22.
Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education.
This case-control study was performed on 107 children aged 2-14 years, 56 children with subclinical hypothyroidism in the case group, and 51 healthy children in the control group presenting to Ayatollah Mousavi Hospital in Zanjan and private clinics of Zanjan city. Thyroid stimulating hormone, triiodothyronine, thyroxine, creatinine, and uric acid were measured in both groups of children after obtaining the necessary criteria for entering the study.
Compared to the control group, subjects with subclinical hypothyroidism had higher levels of creatinine (=0.003), while serum uric acid levels in subclinical hypothyroid children was not significantly different from those in the control group (=0.200).
In subclinical hypothyroidism in children, creatinine was higher than in euthyroid patients, but uric acid was not different.
甲状腺功能减退症是一种临床综合征，可通过导致肾功能受损而使血清肌酐和尿酸水平升高。尽管已经对显性甲状腺功能减退症与肾功能之间的关系进行了许多研究，但针对亚临床甲状腺功能减退症与肾功能的研究较少，尤其是在儿科患者中。因此，我们对儿童中的这一问题进行了研究，以便为更有价值的研究和未来教育提供背景资料。
本病例对照研究对107名2至14岁的儿童进行，病例组为56名亚临床甲状腺功能减退症儿童，对照组为51名健康儿童，他们均来自赞詹的阿亚图拉·穆萨维医院和赞詹市的私人诊所。在获得进入研究的必要标准后，对两组儿童测量促甲状腺激素、三碘甲状腺原氨酸、甲状腺素、肌酐和尿酸。
与对照组相比，亚临床甲状腺功能减退症患者的肌酐水平更高（=0.003），而亚临床甲状腺功能减退症儿童的血清尿酸水平与对照组无显著差异（=0.200）。
在儿童亚临床甲状腺功能减退症中，肌酐水平高于甲状腺功能正常的患者，但尿酸水平无差异。
