Kaur Premjeet, Suri Vijay
Department of Biochemistry, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
Dr Vijay Suri, Department of pathology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
EJIFCC. 2024 Aug 8;35(2):83-90. eCollection 2024 Aug.
Overt hypothyroidism is associated with high levels of serum uric acid (UA) however, the association between UA and thyroid function in patients with subclinical thyroid dysfunction remains unclear. Subclinical hypothyroidism (SCH) is a common endocrine disorder characterized by normal thyroxine (T4) and triiodothyronine (T3), and elevated thyroid stimulating hormone (TSH) levels, usually without clinical manifestations. Therefore, we carried out a study of patients with subclinical thyroid dysfunction to assess the relationship between thyroid function and UA. This lead us to review the literature to find to what extent subclinical hypothyroidism is associated with uric acid. This study adopts the method of retrospective analysis to collect general information and laboratory results aimed at assessing the correlation between uric acid and thyroid hormone levels. We searched 3 databases using different keywords. Literature search was done for articles published in the last ten years, between 2013-2023. All relevant studies were screened. A total of eighteen articles were finalized for the review. Some studies supported T3 supplementation resulting in SCH correction. Our study indicates that it is important to screen for serum uric acid levels routinely in patients with subclinical hypothyroidism.
显性甲状腺功能减退与血清尿酸（UA）水平升高有关，然而，亚临床甲状腺功能障碍患者中尿酸与甲状腺功能之间的关联仍不清楚。亚临床甲状腺功能减退（SCH）是一种常见的内分泌疾病，其特征是甲状腺素（T4）和三碘甲状腺原氨酸（T3）正常，而促甲状腺激素（TSH）水平升高，通常无临床表现。因此，我们对亚临床甲状腺功能障碍患者进行了一项研究，以评估甲状腺功能与尿酸之间的关系。这促使我们回顾文献，以了解亚临床甲状腺功能减退与尿酸的关联程度。本研究采用回顾性分析方法收集一般信息和实验室结果，旨在评估尿酸与甲状腺激素水平之间的相关性。我们使用不同的关键词搜索了3个数据库。对2013年至2023年过去十年间发表的文章进行了文献检索。对所有相关研究进行了筛选。最终确定了18篇文章进行综述。一些研究支持补充T3可纠正亚临床甲状腺功能减退。我们的研究表明，对亚临床甲状腺功能减退患者常规筛查血清尿酸水平很重要。
