Boniewska-Bernacka Ewa, Pańczyszyn Anna, Cybulska Natalia
a Department of Biotechnology and Molecular Biology , University of Opole , Opole , Poland.
b GMW - Center for Gynecological and Obstetric Diagnosis , Opole , Poland.
Hum Fertil (Camb). 2019 Jun;22(2):78-87. doi: 10.1080/14647273.2018.1456682. Epub 2018 Apr 2.
In recent years, male infertility has become a growing social problem. Standard diagnostic procedures, based on assessing seminological parameters, are often insufficient to explain the causes of male infertility. Because of this, new markers with better clinical application are being sought. One of the promising markers seems to be an assessment of telomere length of sperm. Sperm telomeres, in contrast to somatic cells, are elongated as men age. The results of some studies suggest that telomere length may be relevant in the case of fertilization and normal embryo development. Literature reports indicate that there is a correlation between telomere length of sperm and abnormal sperm parameters. The measurement of telomere length using the method of quantitative PCR could become a new marker of spermatogenesis, which can be useful for evaluating male reproductive age.
近年来，男性不育已成为一个日益严重的社会问题。基于评估精液学参数的标准诊断程序往往不足以解释男性不育的原因。因此，人们正在寻找具有更好临床应用价值的新标志物。其中一个有前景的标志物似乎是对精子端粒长度的评估。与体细胞不同，随着男性年龄增长，精子端粒会延长。一些研究结果表明，端粒长度在受精和正常胚胎发育过程中可能具有相关性。文献报道指出，精子端粒长度与异常精子参数之间存在关联。使用定量PCR方法测量端粒长度可能成为精子发生的一个新标志物，有助于评估男性生殖年龄。
