a Department of Nuclear Science and Engineering , Nanjing University of Aeronautics and Astronautics , Nanjing , PR China.
c Jiangsu Key Laboratory for Biomaterials and Devices , Southeast University , Nanjing , PR China.
Artif Cells Nanomed Biotechnol. 2018;46(sup1):975-984. doi: 10.1080/21691401.2018.1439843. Epub 2018 Apr 3.
Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of FeO-OA, Ag and FeO@Ag nanoparticles on U251 cells. The results show that FeO@Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of FeO@Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of FeO@Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells.
放射疗法是癌症的主要治疗方法之一，但癌细胞的辐射抗性仍然是一个严重的问题。因此，迫切需要寻找增敏剂来克服这种抗性。本研究的目的是评估和比较 FeO-OA、Ag 和 FeO@Ag 纳米粒子对 U251 细胞的放射增敏作用。结果表明，在这三种纳米粒子中，FeO@Ag 纳米粒子具有最高的放射增敏能力。FeO@Ag 纳米粒子增强放射敏感性的潜在机制是通过降低早期的细胞保护性自噬，并增加晚期的钙依赖性细胞凋亡。这些发现表明，FeO@Ag 纳米粒子作为一种高效的纳米增敏剂，具有治疗神经胶质瘤细胞的潜力。
