Roversi R, Rossi C, Ricci S, Gemelli G, Ciliberti M A
Istituto di Radiologia dell'Università, Bologna.
Radiol Med. 1987 Nov;74(5):413-9.
The authors' experience is reported on intravascular fibrinolytic therapy with urokinase in acute arterial obstructions. Thirty-eight patients were treated, from 1983 to 1986, for acute thrombosis and/or thromboembolization, 22 of which developed on an atherosclerotic lesion, and 10 on a surgical stenotic by-pass graft. A complete vascular recanalization has been obtained, at the end of the procedure, in 69.4% of the cases, 77.7% had a definite final clinical improvement. The results correspond to the medium statistical level of the various casuistics analyzed for comparison. Surgery has been performed on 27.7% of the patients. Complications have been observed in 8% of the cases. IAF technique is of greatest value in the treatment of those lesions; better results have been obtained with intra-thrombus injection of the drug (as emphasized by many authors) in association with PTA and surgery. A close cooperation between interventional radiology, vascular surgery and angiology is therefore necessary in this field.
本文报道了作者使用尿激酶进行血管内溶栓治疗急性动脉阻塞的经验。1983年至1986年期间，38例患者接受了急性血栓形成和/或血栓栓塞治疗，其中22例发生于动脉粥样硬化病变，10例发生于外科狭窄旁路移植血管。在治疗结束时，69.4%的病例实现了完全血管再通，77.7%的患者最终临床症状明显改善。这些结果与用于比较分析的各类病例的中等统计水平相符。27.7%的患者接受了手术治疗。8%的病例观察到并发症。IAF技术在这些病变的治疗中具有最大价值；正如许多作者所强调的，将药物经血栓内注射与经皮腔内血管成形术（PTA）及手术相结合可取得更好的效果。因此，在该领域介入放射学、血管外科和血管病学之间密切合作是必要的。
