三例Rhupus综合征病例报告：类风湿关节炎与系统性红斑狼疮的重叠综合征
Three Case Reports of Rhupus Syndrome: An Overlap Syndrome of Rheumatoid Arthritis and Systemic Lupus Erythematosus.
作者信息
Devrimsel Gul, Serdaroglu Beyazal Munevver
机构信息
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
出版信息
Case Rep Rheumatol. 2018 Jan 21;2018:6194738. doi: 10.1155/2018/6194738. eCollection 2018.
We present the clinical and serological characteristics of three patients with rhupus. The 3 patients with rhupus presented ACR criteria for SLE as well as for RA, ANA positive with a titer of 1/100 in all patients, and positive anti-DNA in 2 of the 3 patients, with the predominance of symmetrical polyarthritis. We found anti-CCP positivity and rheumatoid factor positivity and high titers in all patients, positive anti- anti-SSA in one patient, and positive anti- anti-Sm in one patient. Renal and liver function tests were normal in all patients. The 3 patients achieved clinical remission with DMARD treatment.
我们展示了3例rhupus患者的临床和血清学特征。这3例rhupus患者符合美国风湿病学会（ACR）关于系统性红斑狼疮（SLE）和类风湿关节炎（RA）的标准，所有患者抗核抗体（ANA）均为阳性，滴度为1/100，3例患者中有2例抗双链DNA（anti-DNA）阳性，主要表现为对称性多关节炎。我们发现所有患者抗环瓜氨酸肽（anti-CCP）阳性、类风湿因子（RF）阳性且滴度高，1例患者抗SSA阳性，1例患者抗Sm阳性。所有患者的肾功能和肝功能检查均正常。这3例患者通过改善病情抗风湿药（DMARD）治疗实现了临床缓解。
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